Applications of C-H Functionalization Logic to Cyclobutane Synthesis

被引：167

作者：

Gutekunst, Will R. ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 06期

关键词：

CATALYZED DIRECT ARYLATION; METHYLENE C(SP(3))-H BOND; MULTICOMPONENT REACTIONS; STRUCTURAL REVISION; SCALABLE SYNTHESIS; NATURAL-PRODUCTS; SOLID-STATE; ACID; ACTIVATION; AMIDES;

D O I：

10.1021/jo4027148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

引用

页码：2430 / 2452

页数：23

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