Applications of C-H Functionalization Logic to Cyclobutane Synthesis

被引:167
作者
Gutekunst, Will R. [1 ]
Baran, Phil S. [1 ]
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
关键词
CATALYZED DIRECT ARYLATION; METHYLENE C(SP(3))-H BOND; MULTICOMPONENT REACTIONS; STRUCTURAL REVISION; SCALABLE SYNTHESIS; NATURAL-PRODUCTS; SOLID-STATE; ACID; ACTIVATION; AMIDES;
D O I
10.1021/jo4027148
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.
引用
收藏
页码:2430 / 2452
页数:23
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