PI3K inhibitors as potential therapeutics for autoimmune disease

被引：29

作者：

Ball, Jennifer ^{[1
]}

Archer, Sophie ^{[1
]}

Ward, Stephen ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Claverton Down BA2 7AY, Avon, England

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期

关键词：

RHEUMATOID-ARTHRITIS; PI3K-GAMMA; DELTA; INFLAMMATION; MECHANISMS; INITIATION; CAL-101; ISOFORM; PATHWAY;

D O I：

10.1016/j.drudis.2014.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aberrant overactivation of the immune system can give rise to chronic and persistent self-attack, culminating in autoimmune disease. This is currently managed therapeutically using potent immunosuppressive and anti-inflammatory drugs. Class I phosphoinositide 3-kinases (PI3Ks) have been identified as ideal therapeutic targets for autoimmune diseases given their wide-ranging roles in immunological processes. Recent studies into the function of selective PI3K inhibitors in vitro and in vivo have yielded encouraging results, allowing progression into the clinic. Here, we review their recent progress across a range of autoimmune diseases.

引用

页码：1195 / 1199

页数：5

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