Derivatization for liquid chromatography-mass spectrometry

被引：208

作者：

Qi, Bao-Ling ^{[1
]}

Liu, Ping ^{[1
]}

Wang, Qiu-Yi ^{[1
]}

Cai, Wen-Jing ^{[1
]}

Yuan, Bi-Feng ^{[1
]}

Feng, Yu-Qi ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2014年 / 59卷

基金：

中国国家自然科学基金;

关键词：

Derivatization; Environmental analysis; Food-safety evaluation; Liquid chromatography; Mass spectrometric imaging; Mass spectrometry; Metabolite; Peptide; Pharmaceutical analysis; Protein; SOLID-PHASE EXTRACTION; DANSYL CHLORIDE DERIVATIZATION; IN-SITU DERIVATIZATION; CONGENITAL ADRENAL-HYPERPLASIA; DRIED BLOOD SPOTS; PRECOLUMN DERIVATIZATION; CHEMICAL DERIVATIZATION; HUMAN PLASMA; FLUOROGENIC DERIVATIZATION; CARBOXYLIC-ACIDS;

D O I：

10.1016/j.trac.2014.03.013

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Liquid chromatography-mass spectrometry (LC-MS) is one of the most prominent analytical techniques, due to its inherent selectivity and sensitivity. In LC-MS, chemical derivatizations are frequently used to enhance the MS ionization efficiency and selectivity, to facilitate structure elucidation, and to improve the chromatographic separation. In this review, we present an overview of derivatization-based LC-MS analysis. We summarize the reaction mechanisms of representative derivatization reagents and the selection strategy to guide and to stimulate future studies. Furthermore, we emphasize applications of derivatization in peptide and protein analysis, metabolite analysis, environmental analysis, pharmaceutical analysis, food-safety evaluation and MS imaging. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：121 / 132

页数：12

共 160 条

[61] RESOLUTION OF THE ENANTIOMERS OF THIOL COMPOUNDS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY USING CHIRAL DERIVATIZATION WITH 2,3,4,6-TETRA-O-ACETYL-BETA-D-GLUCOPYRANOSYL ISOTHIOCYANATE [J].

ITO, S ;

OTA, A ;

YAMAMOTO, K ;

KAWASHIMA, Y .

JOURNAL OF CHROMATOGRAPHY, 1992, 626 (02) :187-196

[62] Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates [J].

Ji, Chengjie ;

Li, Wenlin ;

Ren, Xiao-dan ;

El-Kattan, Ayman F. ;

Kozak, Rouba ;

Fountain, Scott ;

Lepsy, Christopher .

ANALYTICAL CHEMISTRY, 2008, 80 (23) :9195-9203

[63] A modified Girard derivatizing reagent for universal profiling and trace analysis of aldehydes and ketones by electrospray ionization tandem mass spectrometry [J].

Johnson, David W. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (18) :2926-2932

[64] Fast and sensitive liquid chromatography-mass spectrometry assay for seven androgenic and progestagenic steroids in human serum [J].

Keski-Rahkonen, Pekka ;

Huhtinen, Kaisa ;

Poutanen, Matti ;

Auriola, Seppo .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 127 (3-5) :396-404

[65] Simple derivatization of aldehydes with D-cysteine and their determination in beverages by liquid chromatography-tandem mass spectrometry [J].

Kim, Hyun-Ji ;

Shin, Ho-Sang .

ANALYTICA CHIMICA ACTA, 2011, 702 (02) :225-232

[66] Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry [J].

Kirk, JM ;

Tarbin, J ;

Keely, BJ .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (08) :1247-1252

[67] Comprehensive fluorogenic derivatization-liquid chromatography/tandem mass spectrometry proteomic analysis of colorectal cancer cell to identify biomarker candidate [J].

Koshiyama, Akiyo ;

Ichibangase, Tomoko ;

Imai, Kazuhiro .

BIOMEDICAL CHROMATOGRAPHY, 2013, 27 (04) :440-450

[68] Liquid Chromatography-Tandem Mass Spectrometry Assay for Androstenedione, Dehydroepiandrosterone, and Testosterone with Pediatric and Adult Reference Intervals [J].

Kushnir, Mark M. ;

Blamires, Takara ;

Rockwood, Alan L. ;

Roberts, William L. ;

Yue, Bingfang ;

Erdogan, Evrim ;

Bunker, Ashley M. ;

Meikle, A. Wayne .

CLINICAL CHEMISTRY, 2010, 56 (07) :1138-1147

[69] Performance characteristics of a novel tandem mass spectrometry assay for serum testosterone [J].

Kushnir, MM ;

Rockwood, AL ;

Roberts, WL ;

Pattison, EG ;

Bunker, AM ;

Fitzgerald, RL ;

Meikle, AW .

CLINICAL CHEMISTRY, 2006, 52 (01) :120-128

[70] Fast liquid chromatography/tandem mass spectrometry determination of cannabinoids in micro volume blood samples after dabsyl derivatization [J].

Lacroix, C. ;

Saussereau, E. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2012, 905 :85-95

← 2 3 4 5 6 7 8 9 10 11 →