Derivatization for liquid chromatography-mass spectrometry

被引：208
作者：
Qi, Bao-Ling [1 ]
Liu, Ping [1 ]
Wang, Qiu-Yi [1 ]
Cai, Wen-Jing [1 ]
Yuan, Bi-Feng [1 ]
Feng, Yu-Qi [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2014年 / 59卷
基金：
中国国家自然科学基金;
关键词：
Derivatization; Environmental analysis; Food-safety evaluation; Liquid chromatography; Mass spectrometric imaging; Mass spectrometry; Metabolite; Peptide; Pharmaceutical analysis; Protein; SOLID-PHASE EXTRACTION; DANSYL CHLORIDE DERIVATIZATION; IN-SITU DERIVATIZATION; CONGENITAL ADRENAL-HYPERPLASIA; DRIED BLOOD SPOTS; PRECOLUMN DERIVATIZATION; CHEMICAL DERIVATIZATION; HUMAN PLASMA; FLUOROGENIC DERIVATIZATION; CARBOXYLIC-ACIDS;
D O I：
10.1016/j.trac.2014.03.013
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Liquid chromatography-mass spectrometry (LC-MS) is one of the most prominent analytical techniques, due to its inherent selectivity and sensitivity. In LC-MS, chemical derivatizations are frequently used to enhance the MS ionization efficiency and selectivity, to facilitate structure elucidation, and to improve the chromatographic separation. In this review, we present an overview of derivatization-based LC-MS analysis. We summarize the reaction mechanisms of representative derivatization reagents and the selection strategy to guide and to stimulate future studies. Furthermore, we emphasize applications of derivatization in peptide and protein analysis, metabolite analysis, environmental analysis, pharmaceutical analysis, food-safety evaluation and MS imaging. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：121 / 132
页数：12
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