Preparation, Characterization and Drug Release Studies from Poly(D,L-lactic acid)/organoclay Nanocomposite Films

被引：12

作者：

Stathokostopoulou, C. ^{[1
]}

Tarantili, P. A. ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Sch Chem Engn, Polymer Technol Lab, GR-15780 Athens, Greece

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2014年 / 51卷 / 02期

关键词：

POLYLACTIDE/LAYERED SILICATE NANOCOMPOSITES; POLY(LACTIC ACID) NANOCOMPOSITES; HYDROLYTIC DEGRADATION; POLYLACTIDE/MONTMORILLONITE NANOCOMPOSITES; ORGANOCLAYS;

D O I：

10.1080/10601325.2014.864920

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Biocompatible/biodegradable poly(D,L-lactic acid)/layered silicate nanocomposites were prepared by the solution-intercalation film casting technique. The obtained nanocomposites present a shift of glass transition temperature (Tg) to higher values. An increase in the onset temperature of thermal degradation (Tonset) was also observed by TGA. Hydrolytic degradation of PLA nanocomposites becomes apparent after the first 3 months of immersion of specimens into deionized water. Drug release studies from PLA/organoclay nanocomposite membranes showed slightly faster release behavior in comparison with unreinforced specimens containing 5 phr guaifenesin (GFN), whereas the different organic clay modifications studied in this work, did not seem to have any effect in the release profile of GFN. © 2014 Copyright Taylor and Francis Group, LLC.

引用

页码：117 / 124

页数：8

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