The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer

被引：19
作者：
Cheng, Yue [1 ]
Wang, Meiqi [1 ]
Zhou, Junliang [1 ]
Dong, Huanhuan [1 ]
Wang, Shuqing [1 ]
Xu, Hui [1 ]
机构：
[1] Harbin Med Univ, Canc Hosp, Dept Clin Lab, 150 Haping Rd, Harbin 150081, Peoples R China
来源：
GENES | 2021年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
N6-methyladenosine (m(6)A); methyltransferases; demethylases; m(6)A-binding proteins; NSCLC; EPITHELIAL-MESENCHYMAL TRANSITION; MYC MESSENGER-RNA; NUCLEAR-RNA; YTH DOMAIN; M(6)A; PROLIFERATION; METHYLATION; TRANSLATION; PROTEINS; BINDING;
D O I：
10.3390/genes12030440
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
N6-methyladenosine (m(6)A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m(6)A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m(6)A methyltransferases, demethylases and m(6)A-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the m(6)A modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various m(6)A regulators modulate m(6)A RNA metabolism and demonstrated the effect of m(6)A modification on the progression and cellular biological functions of NSCLC. We also discussed how m(6)A modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients.
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页数：15
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