Two-axis MEMS scanning catheter for ultrahigh resolution three-dimensional and en face imaging

被引：102
作者：
Aguirre, Aaron D.
Herz, Paul R.
Chen, Yu
Fujimoto, James G.
Piyawattanametha, Wibool
Fan, Li
Wu, Ming C.
机构：
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[4] Univ Calif Berkeley, Integrated Photon Lab, Berkeley, CA 94720 USA
来源：
OPTICS EXPRESS | 2007年 / 15卷 / 05期
关键词：
D O I：
10.1364/OE.15.002445
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Ultrahigh resolution two and three-dimensional optical coherence tomography (OCT) imaging was performed using a miniaturized, two-axis scanning catheter based upon microelectromechanical systems (MEMS) mirror technology. The catheter incorporated a custom-designed and fabricated, 1-mm diameter MEMS mirror driven by angular vertical comb (AVC) actuators on both an inner mirror axis and an outer, orthogonal gimbal axis. Using a differential drive scheme, a linearized position response over +/- 6 degrees mechanical angle was achieved. The flexible, fiber-optic catheter device measured < 5 mm in outer diameter with a rigid length of similar to 2.5 cm at the distal end. In vivo and ex vivo images are presented with < 4 mu m axial and similar to 12 mu m transverse resolution in tissue. (c) 2007 Optical Society of America.
引用
收藏
页码：2445 / 2453
页数：9
相关论文
共 38 条
[21]   In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve [J].
Nassif, NA ;
Cense, B ;
Park, BH ;
Pierce, MC ;
Yun, SH ;
Bouma, BE ;
Tearney, GJ ;
Chen, TC ;
de Boer, JF .
OPTICS EXPRESS, 2004, 12 (03) :367-376
[22]   Endoscopic optical coherence tomography based on a microelectromechanical mirror [J].
Pan, YT ;
Xie, HK ;
Fedder, GK .
OPTICS LETTERS, 2001, 26 (24) :1966-1968
[23]  
PATTERSON PR, 2002, 15 IEEE INT C MICR E
[24]  
PIYAWATTANAMETH.W, 2004, C LAS EL CLEO SAN FR
[25]  
PIYAWATTANAMETH.W, 2006, IEEE LEOS INT C OPT
[26]  
PIYAWATTANAMETH.W, 2001, P 11 INT C SOL STAT
[27]   A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract [J].
Polglase, AL ;
McLaren, WJ ;
Skinner, SA ;
Kiesslich, R ;
Neurath, MF ;
Delaney, PM .
GASTROINTESTINAL ENDOSCOPY, 2005, 62 (05) :686-695
[28]   Diagnosis of specialized intestinal metaplasia by optical coherence tomography [J].
Poneros, JM ;
Brand, S ;
Bouma, BE ;
Tearney, GJ ;
Compton, CC ;
Nishioka, NS .
GASTROENTEROLOGY, 2001, 120 (01) :7-12
[29]   Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror [J].
Qi, B ;
Himmer, AP ;
Gordon, LM ;
Yang, XDV ;
Dickensheets, LD ;
Vitkin, IA .
OPTICS COMMUNICATIONS, 2004, 232 (1-6) :123-128
[30]   Virtual histology of colorectal lesions using laser-scanning confocal microscopy [J].
Sakashita, M ;
Inoue, H ;
Kashida, H ;
Tanaka, J ;
Cho, JY ;
Satodate, H ;
Hidaka, E ;
Yoshida, T ;
Fukami, N ;
Tamegai, Y ;
Shiokawa, A ;
Kudo, S .
ENDOSCOPY, 2003, 35 (12) :1033-1038
1234