Two-axis MEMS scanning catheter for ultrahigh resolution three-dimensional and en face imaging

被引:102
作者
Aguirre, Aaron D.
Herz, Paul R.
Chen, Yu
Fujimoto, James G.
Piyawattanametha, Wibool
Fan, Li
Wu, Ming C.
机构
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA
[4] Univ Calif Berkeley, Integrated Photon Lab, Berkeley, CA 94720 USA
关键词
D O I
10.1364/OE.15.002445
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Ultrahigh resolution two and three-dimensional optical coherence tomography (OCT) imaging was performed using a miniaturized, two-axis scanning catheter based upon microelectromechanical systems (MEMS) mirror technology. The catheter incorporated a custom-designed and fabricated, 1-mm diameter MEMS mirror driven by angular vertical comb (AVC) actuators on both an inner mirror axis and an outer, orthogonal gimbal axis. Using a differential drive scheme, a linearized position response over +/- 6 degrees mechanical angle was achieved. The flexible, fiber-optic catheter device measured < 5 mm in outer diameter with a rigid length of similar to 2.5 cm at the distal end. In vivo and ex vivo images are presented with < 4 mu m axial and similar to 12 mu m transverse resolution in tissue. (c) 2007 Optical Society of America.
引用
收藏
页码:2445 / 2453
页数:9
相关论文
共 38 条
[1]   High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging [J].
Aguirre, AD ;
Hsiung, P ;
Ko, TH ;
Hartl, I ;
Fujimoto, JG .
OPTICS LETTERS, 2003, 28 (21) :2064-2066
[2]   Forward-imaging instruments for optical coherence tomography [J].
Boppart, SA ;
Bouma, BE ;
Pitris, C ;
Tearney, GJ ;
Fujimoto, JG ;
Brezinski, ME .
OPTICS LETTERS, 1997, 22 (21) :1618-1620
[3]   High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography [J].
Bouma, BE ;
Tearney, GJ ;
Compton, CC ;
Nishioka, NS .
GASTROINTESTINAL ENDOSCOPY, 2000, 51 (04) :467-474
[4]   Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber [J].
Bourquin, S ;
Aguirre, AD ;
Hartl, I ;
Hsiung, P ;
Ko, TH ;
Fujimoto, JG ;
Birks, TA ;
Wadsworth, WJ ;
Bünting, U ;
Kopf, D .
OPTICS EXPRESS, 2003, 11 (24) :3290-3297
[5]   Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source [J].
Choma, MA ;
Hsu, K ;
Izatt, JA .
JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (04)
[6]   Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].
Choma, MA ;
Sarunic, MV ;
Yang, CH ;
Izatt, JA .
OPTICS EXPRESS, 2003, 11 (18) :2183-2189
[7]   Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].
de Boer, JF ;
Cense, B ;
Park, BH ;
Pierce, MC ;
Tearney, GJ ;
Bouma, BE .
OPTICS LETTERS, 2003, 28 (21) :2067-2069
[8]   Silicon-micromachined scanning confocal optical microscope [J].
Dickensheets, DL ;
Kino, GS .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 1998, 7 (01) :38-47
[9]   A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals [J].
Helmchen, F ;
Fee, MS ;
Tank, DW ;
Denk, W .
NEURON, 2001, 31 (06) :903-912
[10]   Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography [J].
Huber, R ;
Wojtkowski, M ;
Fujimoto, JG .
OPTICS EXPRESS, 2006, 14 (08) :3225-3237