Spectroscopic approaches for the study of high-pressure fluid systems

The utilization of supercritical fluids as a solvent medium in analysis has been on the rise over the past two decades. The study of analytically relevant supercritical fluid systems through standard spectroscopic techniques presents unique challenges due to the extreme conditions that must be realized. This is also true of the study of biological macromolecules under extreme conditions of temperature and pressure. This presentation will focus on the spectroscopic approaches that we have developed and utilized to study these systems ranging from microvolume techniques to standard high-pressure vessels.