Biomolecular condensates: organizers of cellular biochemistry

被引：3890

作者：

Banani, Salman F. ^{[1
,2
]}

Lee, Hyun O. ^{[3
]}

Hyman, Anthony A. ^{[3
]}

Rosen, Michael K. ^{[1
,2
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[3] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 05期

关键词：

RNA-BINDING PROTEINS; PML NUCLEAR-BODIES; INTRINSICALLY DISORDERED PROTEINS; EUKARYOTIC STRESS GRANULES; LOW-COMPLEXITY DOMAINS; C-TERMINAL DOMAIN; JURKAT T-CELLS; PHASE-TRANSITION; SACCHAROMYCES-CEREVISIAE; IMMUNOLOGICAL SYNAPSE;

D O I：

10.1038/nrm.2017.7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes but function to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. Recent studies have shown that liquid-liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates. With this physical framework, it is now possible to explain how the assembly, composition, physical properties and biochemical and cellular functions of these important structures are regulated.

引用

页码：285 / 298

页数：14

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