Allostatic load and reduced cortical thickness in schizophrenia

被引:41
作者
Chiappelli, Joshua [1 ]
Kochunov, Peter [1 ]
Savransky, Anya [1 ]
Fisseha, Feven [1 ]
Wisner, Krista [1 ]
Du, Xiaoming [1 ]
Rowland, Laura M. [1 ]
Hong, L. Elliot [1 ]
机构
[1] Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
基金
美国国家卫生研究院;
关键词
Schizophrenia; Cortical thickness; Allostatic load; Stress; C-reactive protein; C-REACTIVE PROTEIN; MEDIAL PREFRONTAL CORTEX; HUMAN CEREBRAL-CORTEX; 1ST-EPISODE SCHIZOPHRENIA; PLASMA NOREPINEPHRINE; SPECTRUM DISORDERS; PSYCHOSIS FINDINGS; BRAIN STRUCTURE; CHRONIC STRESS; RISK;
D O I
10.1016/j.psyneuen.2016.11.021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Structural imaging studies have consistently found reduced gray matter thickness of the cerebral cortex in schizophrenia, a finding that is evident in first episode psychosis and may be progressive in some cases. Although genetic predisposition and medication effects may contribute to cortical thinning, we hypothesize that the cumulative effects of stress may represent an environmental factor impacting brain morphology in schizophrenia. We examined the relationship between allostatic load, an index of peripheral biomarkers representing the cumulative effects of stress, and cortical thickness. Allostatic load was calculated for 44 patients with schizophrenia spectrum disorders (SSD) and 33 normal controls (NC) based on 13 cardiovascular, neuroendocrine, immune, and metabolic measurements. Controlling for age, SSD had significantly elevated allostatic load as compared with NC (p = 0.008). Controlling for age, whole brain average cortical thickness was lower in SSD patients compared to NC (p = 0.008). However, once allostatic load was accounted for, the group difference in cortical thickness became marginal (p = 0.058). Exploratory analyses on subcomponents of allostatic load suggested that elevated immune marker C-reactive protein, stress hormones, and cardiovascular indices within allostatic load were more strongly associated with reduced cortical thickness in SSD. In NC, only the association between immune marker C-reactive protein and cortical thickness was replicated. These results support the hypothesis that allostatic load may account for some of the gray matter deficits observed in schizophrenia. Among the allostatic indices, the inflammatory mechanism appears particularly relevant to cortical thickness in both schizophrenia patients and normal controls. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:105 / 111
页数:7
相关论文
共 48 条
[1]   Prolonged corticosterone exposure induces dendritic spine remodeling and attrition in the rat medial prefrontal cortex [J].
Anderson, Rachel M. ;
Glanz, Ryan M. ;
Johnson, Shane B. ;
Miller, Mary M. ;
Romig-Martin, Sara A. ;
Radley, Jason J. .
JOURNAL OF COMPARATIVE NEUROLOGY, 2016, 524 (18) :3729-3746
[2]   Association of allostatic load with brain structure and cognitive ability in later life [J].
Booth, Tom ;
Royle, Natalie A. ;
Corley, Janie ;
Gow, Alan J. ;
Hernandez, Maria del C. Valdes ;
Maniega, Susana Munoz ;
Ritchie, Stuart J. ;
Bastin, Mark E. ;
Starr, John M. ;
Wardlaw, Joanna M. ;
Deary, Ian J. .
NEUROBIOLOGY OF AGING, 2015, 36 (03) :1390-1399
[3]   THE EFFECT OF CLOZAPINE ON PLASMA NOREPINEPHRINE - RELATIONSHIP TO CLINICAL EFFICACY [J].
BREIER, A ;
BUCHANAN, RW ;
WALTRIP, RW ;
LISTWAK, S ;
HOLMES, C ;
GOLDSTEIN, DS .
NEUROPSYCHOPHARMACOLOGY, 1994, 10 (01) :1-7
[4]   Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex [J].
Brown, SM ;
Henning, S ;
Wellman, CL .
CEREBRAL CORTEX, 2005, 15 (11) :1714-1722
[5]   Chronic Peripheral Inflammation is Associated With Cognitive Impairment in Schizophrenia: Results From the Multicentric FACE-SZ Dataset [J].
Bulzacka, Ewa ;
Boyer, Laurent ;
Schurhoff, Franck ;
Godin, Ophelia ;
Berna, Fabrice ;
Brunel, Lore ;
Andrianarisoa, Meja ;
Aouizerate, Bruno ;
Capdevielle, Delphine ;
Chereau-Boudet, Isabelle ;
Chesnoy-Servanin, Gabrielle ;
Danion, Jean-Marie ;
Dubertret, Caroline ;
Dubreucq, Julien ;
Faget, Catherine ;
Gabayet, Franck ;
Le Gloahec, Tifenn ;
Llorca, Pierre-Michel ;
Mallet, Jasmina ;
Misdrahi, David ;
Rey, Romain ;
Richieri, Raphaelle ;
Passerieux, Christine ;
Roux, Paul ;
Yazbek, Hanan ;
Leboyer, Marion ;
Fond, Guillaume .
SCHIZOPHRENIA BULLETIN, 2016, 42 (05) :1290-1302
[6]   Cardiometabolic Risk in Patients With First-Episode Schizophrenia Spectrum Disorders Baseline Results From the RAISE-ETP Study [J].
Correll, Christoph U. ;
Robinson, Delbert G. ;
Schooler, Nina R. ;
Brunette, Mary F. ;
Mueser, Kim T. ;
Rosenheck, Robert A. ;
Marcy, Patricia ;
Addington, Jean ;
Estroff, Sue E. ;
Robinson, James ;
Penn, David L. ;
Azrin, Susan ;
Goldstein, Amy ;
Severe, Joanne ;
Heinssen, Robert ;
Kane, John M. .
JAMA PSYCHIATRY, 2014, 71 (12) :1350-1363
[7]   Limbic Scars: Long-Term Consequences of Childhood Maltreatment Revealed by Functional and Structural Magnetic Resonance Imaging [J].
Dannlowski, Udo ;
Stuhrmann, Anja ;
Beutelmann, Victoria ;
Zwanzger, Peter ;
Lenzen, Thomas ;
Grotegerd, Dominik ;
Domschke, Katharina ;
Hohoff, Christa ;
Ohrmann, Patricia ;
Bauer, Jochen ;
Lindner, Christian ;
Postert, Christian ;
Konrad, Carsten ;
Arolt, Volker ;
Heindel, Walter ;
Suslow, Thomas ;
Kugel, Harald .
BIOLOGICAL PSYCHIATRY, 2012, 71 (04) :286-293
[8]   Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder [J].
Dickerson, Faith ;
Stallings, Cassie ;
Origoni, Andrea ;
Vaughan, Crystal ;
Khushalani, Sunil ;
Yolken, Robert .
JOURNAL OF AFFECTIVE DISORDERS, 2013, 150 (02) :456-459
[9]   C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications [J].
Fernandes, B. S. ;
Steiner, J. ;
Bernstein, H-G ;
Dodd, S. ;
Pasco, J. A. ;
Dean, O. M. ;
Nardin, P. ;
Goncalves, C-A ;
Berk, M. .
MOLECULAR PSYCHIATRY, 2016, 21 (04) :554-564
[10]   Automatically parcellating the human cerebral cortex [J].
Fischl, B ;
van der Kouwe, A ;
Destrieux, C ;
Halgren, E ;
Ségonne, F ;
Salat, DH ;
Busa, E ;
Seidman, LJ ;
Goldstein, J ;
Kennedy, D ;
Caviness, V ;
Makris, N ;
Rosen, B ;
Dale, AM .
CEREBRAL CORTEX, 2004, 14 (01) :11-22