Natural history of immediate-type hen's egg allergy in Japanese children

被引：51

作者：

Ohtani, Kiyotaka ^{[1
,2
]}

Sato, Sakura ^{[1
]}

Syukuya, Akinori ^{[3
]}

Asaumi, Tomoyuki ^{[4
]}

Ogura, Kiyotake ^{[1
]}

Koike, Yumi ^{[5
]}

Iikura, Katsuhito ^{[4
]}

Yanagida, Noriyuki ^{[4
]}

Imai, Takanori ^{[1
,6
]}

Ebisawa, Motohiro ^{[1
]}

机构：

[1] Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan

[2] Sagamihara Kyodo Hosp, Dept Pediat, Sagamihara, Kanagawa, Japan

[3] Futaba Kodomo Clin, Tokyo, Japan

[4] Sagamihara Natl Hosp, Dept Pediat, Sagamihara, Kanagawa, Japan

[5] Nagano Childrens Hosp, Dept Gen Med, Nagano, Japan

[6] Showa Univ, Dept Pediat, Tokyo, Japan

来源：

ALLERGOLOGY INTERNATIONAL | 2016年 / 65卷 / 02期

关键词：

Egg white-specific immunoglobulin E (IgE) antibodies; Hen's egg; Oral food challenge; Ovomucoid-specific IgE; Tolerance acquisition; FOOD CHALLENGES; TOLERANCE; GUIDELINE;

D O I：

10.1016/j.alit.2015.10.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Hen's egg (HE) allergy develops during infancy. We investigated tolerance acquisition in Japanese children allergic to HE aging <6 years. Methods: In this retrospective study, 226 children born in 2005 with a history of immediate-type HE allergy underwent an oral food challenge (OFC). Tolerance was defined as no reaction to an OFC with half of whole heated HE or accidental HE consumption at home. Participants were divided into three groups based on age at tolerance acquisition: group I (<3 years) (n = 66), group II (3-6 years) (n = 98), and group III (prolonged allergic groups) (n = 62). Results: Tolerance acquisition occurred in 30% (66/226) by 3 years of age, 59% (133/226) by 5 years of age, and 73% (164/226) at 6 years of age. At 3 years, incidences of allergy-related complications (bronchial asthma, p = 0.02; atopic dermatitis, p = 0.04) were higher in the group III than in the group I. Anaphylaxis to any food occurred more frequently in the group III than in the group I (p = 0.03); anaphylaxis to HE was more common in the group III (p = 0.04). Egg white (EW)- and ovomucoid (OM)specific immunoglobulin E (IgE) levels were higher in the group III than in the group I (p < 0.05). Conclusions: The group III experienced HE-related anaphylaxis and complications more frequently and exhibited sustained, high EW- and OM-specific IgE levels. Copyright (C) 2015, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：153 / 157

页数：5

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