Polyurethane/poly(lactic-co-glycolic) acid composite scaffolds fabricated by thermally induced phase separation

被引:115
作者
Rowlands, A. S.
Lim, S. A.
Martin, D.
Cooper-White, J. J. [1 ]
机构
[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Tissue Engn & Microfluid Lab, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Sch Engn, Brisbane, Qld 4072, Australia
基金
澳大利亚研究理事会;
关键词
composite; scaffold; polyurethane; polylactic acid; mechanical properties; cell spreading;
D O I
10.1016/j.biomaterials.2006.12.032
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this study, we present a novel composite scaffold fabricated using a thermally induced phase separation (TIPS) process from poly(lactic-co-glycolic) (PLGA) and biomedical polyurethane (PU). This processing method has been tuned to allow intimate (molecular) mixing of these two very different polymers, giving rise to a unique morphology that can be manipulated by controlling the phase separation behaviour of an initially homogenous polymer solution. Pure PLGA scaffolds possessed a smooth, directional fibrous sheet-like structure with pore sizes of 0.1-200 mu m, a porous Young's modulus of 93.5 kPa and were relatively brittle to touch. Pure PU scaffolds had an isotropic emulsion-like structure, a porous Young's modulus of 15.7 kPa and were much more elastic than the PLGA scaffolds. The composite PLGA/PU scaffold exhibits advantageous morphological, mechanical and cell adhesion and growth supporting properties, when compared with scaffolds fabricated from PLGA or PU alone. This novel method provides a mechanism for the formation of tailored bioactivc scaffolds from nominally incompatible polymers, representing a significant step forward in scaffold processing for tissue-engineering applications. (c) 2007 Published by Elsevier Ltd.
引用
收藏
页码:2109 / 2121
页数:13
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