Tumor necrosis factor receptor associated factor-6 inhibited actinomycin D plus TNF-α-Induced cell death

被引：0
|
作者：
Ichikawa, D. [1 ]
Aizu-Yokota, E. [1 ]
Sonoda, Y. [1 ]
Inoue, J. [2 ]
Kasahara, T. [1 ]
机构：
[1] Kyoritsu Univ Pharm, Dept Biochem, Minato Ku, Tokyo, Japan
[2] Univ Tokyo, Inst Med Sci, Div Cellular & Mol Biol, Minato Ku, Tokyo, Japan
来源：
PROCEEDINGS OF THE 6TH INTERNATIONAL CYTOKINE CONFERENCE | 2006年
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Murine embryonic fibroblasts (MEF) derived from TRAF6 knockout mice have increased sensitivity to actinomycin D (ActD) plus TNF-alpha-induced cell death compared with wild-type MER While ActD plus TNF-alpha-induced phosphorylation of JNK and ERK, and degradation of I kappa B alpha were not different between TRAF6(-/-) and wild-type MEF, slightly higher caspase-3 activity was observed in TRAF6(-/-) MER In addition, reactive oxygen species (ROS) were more accumulated in TRAF6(-/-) MEF than in wild-type MEF. An antioxidant, butylated hydroxyanisole (BHA) markedly inhibited cell death in TRAF6(-/-) MEF We assumed that resistance against ActD plus TNF-alpha- induced cell death in MEFs is rendered by TRAF6, which downregulates ROS production.
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页码：91 / +
页数：3
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