PrepMS: TOF MS data graphical preprocessing tool

被引:33
作者
Karpievitch, Yuliya V. [1 ]
Hill, Elizabeth G.
Smolka, Adam J.
Morris, Jeffrey S.
Coombes, Kevin R.
Baggerly, Keith A.
Almeida, Jonas S.
机构
[1] Med Univ S Carolina, Dept Biostat Bioinformat & Epidemiol, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Biostat & Appl Math, Houston, TX 77030 USA
关键词
D O I
10.1093/bioinformatics/btl583
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We introduce a simple-to-use graphical tool that enables researchers to easily prepare time-of-flight mass spectrometry data for analysis. For ease of use, the graphical executable provides default parameter settings, experimentally determined to work well in most situations. These values, if desired, can be changed by the user. PrepMS is a stand-alone application made freely available (open source), and is under the General Public License (GPL). Its graphical user interface, default parameter settings, and display plots allow PrepMS to be used effectively for data preprocessing, peak detection and visual data quality assessment.
引用
收藏
页码:264 / 265
页数:2
相关论文
共 10 条
[1]  
Adam BL, 2002, CANCER RES, V62, P3609
[2]   Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments [J].
Baggerly, KA ;
Morris, JS ;
Coombes, KR .
BIOINFORMATICS, 2004, 20 (05) :777-U710
[3]   High-resolution serum proteomic features for ovarian cancer detection [J].
Conrads, TP ;
Fusaro, VA ;
Ross, S ;
Johann, D ;
Rajapakse, V ;
Hitt, BA ;
Steinberg, SM ;
Kohn, EC ;
Fishman, DA ;
Whiteley, G ;
Barrett, JC ;
Liotta, LA ;
Petricoin, EF ;
Veenstra, TD .
ENDOCRINE-RELATED CANCER, 2004, 11 (02) :163-178
[4]   Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform [J].
Coombes, KR ;
Tsavachidis, S ;
Morris, JS ;
Baggerly, KA ;
Hung, MC ;
Kuerer, HM .
PROTEOMICS, 2005, 5 (16) :4107-4117
[5]  
Koomen JM, 2005, CLIN CANCER RES, V11, P1110
[6]   Enhancement of sensitivity and resolution of surface-enhanced, laser desorption/lonization time-of-flight mass spectrometric records for serum peptides using time-series analysis techniques [J].
Malyarenko, DI ;
Cooke, WE ;
Adam, BL ;
Malik, G ;
Chen, HJ ;
Tracy, ER ;
Trosset, MW ;
Sasinowski, M ;
Semmes, OJ ;
Manos, DM .
CLINICAL CHEMISTRY, 2005, 51 (01) :65-74
[7]   Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum [J].
Morris, JS ;
Coombes, KR ;
Koomen, J ;
Baggerly, KA ;
Kobayashi, R .
BIOINFORMATICS, 2005, 21 (09) :1764-1775
[8]   Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry [J].
Pawlik, TM ;
Fritsche, H ;
Coombes, KR ;
Xiao, LC ;
Krishnamurthy, S ;
Hunt, KK ;
Pusztai, L ;
Chen, JN ;
Clarke, CH ;
Arun, B ;
Hung, MC ;
Kuerer, HM .
BREAST CANCER RESEARCH AND TREATMENT, 2005, 89 (02) :149-157
[9]   Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry [J].
Schaub, S ;
Wilkins, J ;
Weiler, T ;
Sangster, K ;
Rush, D ;
Nickerson, P .
KIDNEY INTERNATIONAL, 2004, 65 (01) :323-332
[10]   A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection [J].
Yasui, Y ;
Pepe, M ;
Thompson, ML ;
Adam, BL ;
Wright, GL ;
Qu, YS ;
Potter, JD ;
Winget, M ;
Thornquist, M ;
Feng, ZD .
BIOSTATISTICS, 2003, 4 (03) :449-463