Human and primate-specific microRNAs in cancer: Evolution, and significance in comparison with more distantly-related research models

被引：20

作者：

Koufaris, Costas ^{[1
]}

机构：

[1] Cyprus Inst Neurol & Genet, Dept Cytogenet & Genom, Nicosia, Cyprus

来源：

BIOESSAYS | 2016年 / 38卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

cancer; evolution; human; lineage; microRNA; mouse; species; specific; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; HUMAN-CELLS; GENES; EXPRESSION; BRAIN; DIFFERENTIATION; IDENTIFICATION; TRANSCRIPTION; CLUSTER;

D O I：

10.1002/bies.201500135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The largest proportion of microRNAs in humans (ca. 40-50%) originated in the phylogenetic grouping defined as primates. The dynamic evolution of this family of noncoding RNA is further demonstrated by the presence of microRNA unique to the human species. Investigations into the role of microRNA in cancer have until recently mainly focused on the more ancient members of this RNA family that are widely conserved in the animal kingdom. As I describe in this review the evolutionary young lineage and species-specific microRNA could be important contributors to cancers, especially in particular organs in primates compared to more distantly-related research models. Elucidating the biological significance of primate and human-specific microRNA in cancer could have important implications for cancer research and the use of nonprimate animal models.

引用

页码：286 / 294

页数：9

共 68 条

[1] Systematic identification of edited microRNAs in the human brain [J].

Alon, Shahar ;

Mor, Eyal ;

Vigneault, Francois ;

Church, George M. ;

Locatelli, Franco ;

Galeano, Federica ;

Gallo, Angela ;

Shomron, Noam ;

Eisenberg, Eli .

GENOME RESEARCH, 2012, 22 (08) :1533-1540

[2] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[3] Global Coevolution of Human MicroRNAs and Their Target Genes [J].

Barbash, Shahar ;

Shifman, Sagiv ;

Soreq, Hermona .

MOLECULAR BIOLOGY AND EVOLUTION, 2014, 31 (05) :1237-1247

[4] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[7] Diversity of microRNAs in human and chimpanzee brain [J].

Berezikov, Eugene ;

Thuemmler, Fritz ;

van Laake, Linda W. ;

Kondova, Ivanela ;

Bontrop, Ronald ;

Cuppen, Edwin ;

Plasterk, Ronald H. A. .

NATURE GENETICS, 2006, 38 (12) :1375-1377

[8] Evolution of microRNA diversity and regulation in animals [J].

Berezikov, Eugene .

NATURE REVIEWS GENETICS, 2011, 12 (12) :846-860

[9] MicroRNAome Genome: A Treasure for Cancer Diagnosis and Therapy [J].

Berindan-Neagoe, Ioana ;

Monroig, Paloma del C. ;

Pasculli, Barbara ;

Calin, George A. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (05) :311-336

[10] A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards [J].

Boobis, Alan R. ;

Cohen, Samuel M. ;

Doerrer, Nancy G. ;

Galloway, Sheila M. ;

Haley, Patrick J. ;

Hard, Gordon C. ;

Hess, Frederick G. ;

Macdonald, James S. ;

Thibault, Stephane ;

Wolf, Douglas C. ;

Wright, Jayne .

TOXICOLOGIC PATHOLOGY, 2009, 37 (06) :714-732

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