The alveolar-epithelial barrier: A target for potential therapy

被引：32

作者：

Budinger, G. R. Scott ^{[1
]}

Sznajder, Jacob I. ^{[1
]}

机构：

[1] Northwestern Univ, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

来源：

CLINICS IN CHEST MEDICINE | 2006年 / 27卷 / 04期

关键词：

D O I：

10.1016/j.ccm.2006.06.007

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

During acute lung injury (ALI), the alveolar-capillary barrier is damaged, resulting in the accumulation of fluid and protein in the alveolar space characteristic of the acute respiratory distress syndrome (ARDS). Disordered epithelial repair may contribute to the development of fibrosis and worsen outcomes in patients who have lung injury. This article discusses novel emerging therapies based on these mechanisms that are designed to preserve the function and promote the repair of the alveolar epithelium in patients who have ALI/ARDS.

引用

页码：655 / +

页数：16

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