Cytogenetic Effects of 18.0 and 16.5 GHz Microwave Radiation on Human Lymphocytes In Vitro

被引：0

作者：

Hansteen, Inger-Lise ^{[3
]}

Lageide, Lars ^{[3
,4
]}

Clausen, Kjell Oskar ^{[3
]}

Haugan, Vera ^{[3
]}

Svendsen, Marit ^{[3
]}

Eriksen, Jan Gunnar ^{[5
]}

Skiaker, Rolf ^{[5
]}

Hauger, Egil ^{[5
]}

Vistnes, Arnt Inge ^{[6
]}

Kure, Elin H. ^{[1
,2
,3
,4
]}

机构：

[1] Oslo Univ Hosp, Mol Oncol Lab, Dept Res & Dev, Ctr Canc, N-0407 Oslo, Norway

[2] Oslo Univ Hosp, Dept Pathol, Sect Mol Pathol, N-0407 Oslo, Norway

[3] Telemark Hosp, Med Genet Sect, Dept Lab Med, Skien, Norway

[4] Telemark Univ Coll, Dept Environm & Hlth Studies, Bo In Telemark, Norway

[5] Telenor Res & Dev, Kjeller, Norway

[6] Univ Oslo, Dept Phys, N-0316 Oslo, Norway

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 08期

关键词：

Chromosomal aberrations; radio frequency; microwave radiation; pulsed-wave; continuous-wave; promotion; PULSED ELECTROMAGNETIC-FIELDS; CHROMOSOMAL-ABERRATIONS; GSM MICROWAVES; MITOMYCIN-C; HEALTH-RISK; EXPOSURE; CANCER; CELLS; INDUCTION; FREQUENCY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There are few cell studies on the direct genotoxic effects of microwave radiation. In this study, cytogenetic effects of microwave radiation alone or in combination with mitomycin C (MMC) were investigated. Materials and Methods: Lymphocytes from two smoking and four non-smoking donors were exposed for 53 hours in vitro to 1.0 W/m(2) continuous-wave radiation at 18.0 GHz or 10 w/m(2) pulsed-wave at 16.5 GHz, alone or in combination with MMC. DNA synthesis and repair were inhibited in vitro in some cultures. Results: No synergistic effect was observed in cells exposed to combinations of microwave radiation and in vitro exposure to MMC, or to cells pre-exposed in vivo to tobacco smoke. For the 16.5 GHz pulsed exposure, a nonsignificant trend consisting of an increase in aberration frequencies with microwave radiation was shown for the DNA synthesis and repair inhibited cultures both with and without MMC. Conclusion: Neither 18.0 GHz continuous-wave nor 16.5 GHz pulsed-wave exposure to human lymphocytes in vitro induced statistically significant increases in chromosomal aberration frequencies. 16.5 GHz pulsed-wave exposure requires further documentation before a true negative conclusion can be drawn.

引用

页码：2885 / 2892

页数：8

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