Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells

被引：87

作者：

Fernando, Pattage Madushan Dilhara Jayatissa ^{[1
]}

Piao, Mei Jing ^{[1
]}

Kang, Kyoung Ah ^{[1
]}

Ryu, Yea Seong ^{[1
]}

Hewage, Susara Ruwan Kumara Madduma ^{[1
]}

Chae, Sung Wook ^{[2
]}

Hyun, Jin Won ^{[1
]}

机构：

[1] Jeju Natl Univ, Sch Med, Dept Biochem, Jeju 63243, South Korea

[2] Korea Inst Oriental Med, Aging Res Ctr, Daejeon 34054, South Korea

来源：

BIOMOLECULES & THERAPEUTICS | 2016年 / 24卷 / 01期

关键词：

Antioxidant system; Oxidative stress; Reactive oxygen species; Rosmarinic acid; Ultraviolet B; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; HEME OXYGENASE-1; HUMAN SKIN; ASSAY; KERATINOCYTES; EXPRESSION; MECHANISM; APOPTOSIS; EXTRACTS;

D O I：

10.4062/biomolther.2015.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to investigate the cytoprotective effect of rasmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.

引用

页码：75 / 84

页数：10

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