Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

被引：15

作者：

Kidd, L. R.

Coulibaly, A.

Templeton, T. M.

Chen, W.

Long, L. O.

Mason, T.

Bonilla, C.

Akereyeni, F.

Freeman, V.

Isaacs, W.

Ahaghotu, C.

Kittles, R. A.

机构：

[1] Univ Louisville, Sch Med,James Graham Brown Canc Ctr, Canc Prevent & Control Program, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA

[2] Howard Univ, Natl Human Genome Ctr, Washington, DC 20059 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[4] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA

[5] Loyola Univ, Stritch Sch Med, Dept Urol, Maywood, IL 60153 USA

[6] Johns Hopkins Med Inst, Brady Urol Inst, Baltimore, MD 21205 USA

[7] Howard Univ Hosp, Div Urol, Washington, DC USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2006年 / 9卷 / 03期

关键词：

bcl-2; apoptosis; prostate cancer;

D O I：

10.1038/sj.pcan.4500884

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant - 938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

引用

页码：284 / 292

页数：9

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