Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

被引：49

作者：

Meador, Catherine B. ^{[1
]}

Micheel, Christine M. ^{[2
,5
]}

Levy, Mia A. ^{[2
,3
,5
]}

Lovly, Christine M. ^{[1
,2
,5
]}

Horn, Leora ^{[2
,5
]}

Warner, Jeremy L. ^{[2
,3
,5
]}

Johnson, Douglas B. ^{[2
,5
]}

Zhao, Zhongming ^{[2
,3
,5
]}

Anderson, Ingrid A. ^{[5
]}

Sosman, Jeffrey A. ^{[2
,5
]}

Vnencak-Jones, Cindy L. ^{[4
,5
]}

Dahlman, Kimberly B. ^{[1
,5
]}

Pao, William ^{[1
,2
,4
,5
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Biomed Informat, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA

[5] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 09期

关键词：

CELL LUNG-CANCER; RECEPTOR TYROSINE KINASE; OPEN-LABEL; BRAF MUTATIONS; PHASE-II; ADVANCED MELANOMA; DOSE-ESCALATION; ACQUIRED-RESISTANCE; THERAPEUTIC TARGET; 1ST-LINE TREATMENT;

D O I：

10.1158/1078-0432.CCR-13-1591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Increased understanding of intertumoral heterogeneity at the genomic level has led to significant advancements in the treatment of solid tumors. Functional genomic alterations conferring sensitivity to targeted therapies can take many forms, and appropriate methods and tools are needed to detect these alterations. This review provides an update on genetic variability among solid tumors of similar histologic classification, using non-small cell lung cancer and melanoma as examples. We also discuss relevant technological platforms for discovery and diagnosis of clinically actionable variants and highlight the implications of specific genomic alterations for response to targeted therapy. (C) 2014 AACR.

引用

页码：2264 / 2275

页数：12

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