Role of eating disorders-related polymorphisms in obesity pathophysiology

被引：22

作者：

Nicoletti, Carolina Ferreira ^{[1
]}

Pereira Delfino, Heitor Bernardes ^{[1
]}

Ferreira, Flavia Campos ^{[1
]}

de Souza Pinhel, Marcela Augusta ^{[1
,2
]}

Nonino, Carla Barbosa ^{[3
]}

机构：

[1] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil

[2] Sao Jose do Rio Preto Med Sch, Lab Studies Biochem & Mol Biol, Dept Mol Biol, Sao Paulo, Brazil

[3] Univ Sao Paulo, Dept Hlth Sci, Ribeirao Preto Med Sch FMRP, Lab Nutrigen Studies, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2019年 / 20卷 / 01期

关键词：

Obesity; Food intake; Eating disorders; Binge eating disorder (BED); Bulimia nervosa (BN); Polymorphism; BODY-MASS INDEX; DOPAMINE-RECEPTOR GENE; BULIMIA-NERVOSA; ANOREXIA-NERVOSA; ENERGY-BALANCE; FOOD-INTAKE; WEIGHT-LOSS; ENVIRONMENTAL-INFLUENCES; BARIATRIC SURGERY; CONTROLLED FAMILY;

D O I：

10.1007/s11154-019-09489-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human biological system provides innumerable neuroendocrine inputs for food intake control, with effects on appetite's modulation and the satiety signs. Its regulation is very complex, engaging several molecular interactions with many tissues, hormones, and neural circuits. Thus, signaling molecules that control food intake are critical for normal energy homeostasis and a deregulation of these pathways can lead to eating disorders and obesity. In line of this, genetic factors have a significantly influence of the regulation of neural circuits controlling the appetite and satiety pathways, as well as the regulation of brain reward systems. Single Nucleotide Polymorphisms (SNPs) in genes related to hypothalamic appetite and satiety mechanisms, further in multiple neurotransmitter systems may contribute to the development of major Eating Disorders (EDs) related to obesity, among them Binge Eating Disorder (BED) and Bulimia Nervosa (BN), which are discussed in this review.

引用

页码：115 / 125

页数：11

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