The genetics of ovarian cancer

被引：47
作者：
Pharoah, PDP [1 ]
Ponder, BAJ [1 ]
机构：
[1] Univ Cambridge, Strangeways Res Lab, Dept Oncol, Cambridge CB1 8RN, England
来源：
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2002年 / 16卷 / 04期
关键词：
family history; risk; genetics; BRCA1; BRCA2;
D O I：
10.1053/beog.2002.0296
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
A family history of ovarian cancer confers an increased risk of ovarian cancer. We review the literature quantifying the familial risks associated with ovarian cancer and assess the evidence that the familial clustering of ovarian cancer is genetically determined. We then describe the known high-penetrance genes, the ovarian cancer risks attached to them and their contribution to ovarian cancer in families and in the general population. The evidence for the existence of other ovarian cancer genes is then considered.
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页码：449 / +
页数：22
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