Cervical Cancer Markers: Epigenetics and microRNAs

被引：107

作者：

Laengsri, Vishuda ^{[1
,2
]}

Kerdpin, Usanee ^{[3
]}

Plabplueng, Chotiros ^{[1
,2
]}

Treeratanapiboon, Lertyot ^{[4
]}

Nuchnoi, Pornlada ^{[1
,2
]}

机构：

[1] Naresuan Univ, Fac Sci, Ctr Res & Innovat, Phitsanulok, Thailand

[2] Naresuan Univ, Fac Sci, Dept Clin Microscopy, Phitsanulok, Thailand

[3] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok, Thailand

[4] Mahidol Univ, Fac Med Technol, Dept Community Med Technol, Bangkok, Thailand

来源：

LABORATORY MEDICINE | 2018年 / 49卷 / 02期

关键词：

cervical cancer; biomarkers; epigenetics; microRNAs; susceptibility; gynecologic malignancy; SQUAMOUS-CELL CARCINOMA; HISTONE DEACETYLASE INHIBITORS; LYMPH-NODE METASTASIS; E6/E7; MESSENGER-RNA; SERUM CYFRA 21-1; DNA METHYLATION; GENE-EXPRESSION; NATURAL-HISTORY; TUMOR-MARKERS; PROMOTER HYPERMETHYLATION;

D O I：

10.1093/labmed/lmx080

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary. This review focuses on the role of epigenetic changes, particularly microRNAs (miRNAs), to CC. Several miRNAs that associated with CC potentially have the advantage of being early biomarkers. Moreover, altered serum miRNAs or single nucleotide polymorphisms in miRNA patterns may predict disease progression.

引用

页码：97 / 111

页数：15

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