Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4

被引：3

作者：

Zhu, Hui-dan ^{[1
]}

Gu, Ni ^{[1
]}

Wang, Meng ^{[1
]}

Kong, Hong-ru ^{[1
]}

Zhou, Meng-tao ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Peoples R China

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2015年 / 41卷 / 11期

关键词：

Capsaicin; cocktail; CYP; drug-CAP interaction; DRUG INTERACTIONS; INTERINDIVIDUAL VARIATIONS; RED-PEPPER; CAPSAICIN; ENZYMES; PHARMACOKINETICS; INHIBITION; OXIDATION; INDUCTION; INGESTION;

D O I：

10.3109/03639045.2015.1011166

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to the frequent consumption of capsaicin (CAP) and its current therapeutic application, the correct assessment of this compound is important from a public health standpoint. The purpose of this study was to find out whether CAP affects rat cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C19, and CYP3A4) by using cocktail probe drugs in vivo. A cocktail solution at a dose of 5mL/kg, which contained phenacetin (15mg/kg), omeprazole (15mg/kg), and midazolam (10mg/kg), was given orally to rats treated for 7d with oral administration of CAP. Blood samples were collected at a series of time-points and the concentrations of probe drugs in plasma were determined by HPLC-MS. The results showed that treatment with multiple doses of CAP had no significant effect on rat CYP1A2. However, CAP had a significant inhibitory effect on CYP2C19 and an inductive effect on CYP3A4. Therefore, caution is needed when CAP is co-administered with some CYP substrates clinically because of potential drug-CAP interactions.

引用

页码：1824 / 1828

页数：5

共 30 条

[1] Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin [J].

Babbar, Sunita ;

Chanda, Sanjay ;

Bley, Keith .

XENOBIOTICA, 2010, 40 (12) :807-816

[2] Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects [J].

Belza, A. ;

Frandsen, E. ;

Kondrup, J. .

INTERNATIONAL JOURNAL OF OBESITY, 2007, 31 (01) :121-130

[3] The Two Faces of Capsaicin [J].

Bode, Ann M. ;

Dong, Zigang .

CANCER RESEARCH, 2011, 71 (08) :2809-2814

[4] INTERINDIVIDUAL VARIATIONS IN DRUG DISPOSITION - CLINICAL IMPLICATIONS AND METHODS OF INVESTIGATION [J].

BREIMER, DD .

CLINICAL PHARMACOKINETICS, 1983, 8 (05) :371-377

[5] Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France [J].

Danton, Anne Charlotte ;

Montastruc, Francois ;

Sommet, Agnes ;

Durrieu, Genevieve ;

Bagheri, Haleh ;

Bondon-Guitton, Emmanuelle ;

Lapeyre-Mestre, Maryse ;

Montastruc, Jean-Louis .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 69 (04) :885-888

[6] Chemical and Pharmacological Aspects of Capsaicin [J].

de Lourdes Reyes-Escogido, Maria ;

Gonzalez-Mondragon, Edith G. ;

Vazquez-Tzompantzi, Erika .

MOLECULES, 2011, 16 (02) :1253-1270

[7]

Díaz-Laviada I, 2010, FUTURE ONCOL, V6, P1545, DOI [10.2217/fon.10.117, 10.2217/FON.10.117]

[8] Time-course effects of St John's wort on the pharmacokinetics of cyclosporine in dogs [J].

Fukunaga, K. ;

Orito, K. .

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2012, 35 (05) :446-451

[9] BIOCHEMISTRY AND MOLECULAR-BIOLOGY OF THE HUMAN CYP2C SUBFAMILY [J].

GOLDSTEIN, JA ;

DEMORAIS, SMF .

PHARMACOGENETICS, 1994, 4 (06) :285-299

[10] Systematic review of topical capsaicin in the treatment of pruritus [J].

Gooding, Sylvia M. D. ;

Canter, Peter H. ;

Coelho, Helen F. ;

Boddy, Kate ;

Ernst, Edzard .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2010, 49 (08) :858-865

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