Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis

被引：34

作者：

Liu, Ming-Tao ^{[1
]}

Lin, Sheng

Wang, Ying-Hong

He, Wen-Yi

Li, Shuai

Wang, Su-Juan

Yang, Yong-Chun

Shi, Jian-Gong

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Ch, Minist Educ, Beijing 100050, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 01期

关键词：

D O I：

10.1021/ol062725z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-d-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.

引用

页码：129 / 132

页数：4

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