Antiretroviral Therapy Fails to Restore Levels of HIV-1 Restriction miRNAs in PBMCs of HIV-1-infected MSM

被引：12

作者：

Liu, Man-Qing ^{[1
]}

Zhao, Min ^{[2
]}

Kong, Wen-Hua ^{[1
]}

Peng, Jin-Song ^{[1
]}

Wang, Fang ^{[1
]}

Qiu, Hong-Yan ^{[2
]}

Zhu, Ze-Rong ^{[1
]}

Tang, Li ^{[1
]}

Sang, Ming ^{[3
]}

Wu, Jian-Guo ^{[4
]}

Ho, Wen-Zhe ^{[4
,5
]}

Zhou, Wang ^{[1
]}

机构：

[1] Wuhan Ctr Dis Prevent & Control, Dept Virol, Wuhan 430015, Peoples R China

[2] Wuhan Inst Dermatol & Venereol, Wuhan, Peoples R China

[3] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Coll Basic Med Sci, Affiliated Hosp Xiangyang 4,Cent Lab, Shiyan, Peoples R China

[4] Wuhan Univ, State Key Lab Virol, Wuhan 430072, Peoples R China

[5] Temple Univ, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19122 USA

来源：

MEDICINE | 2015年 / 94卷 / 46期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

CD4(+) T-LYMPHOCYTES; MICRORNA EXPRESSION; CELL COUNT; INFECTION; REPLICATION; LATENCY;

D O I：

10.1097/MD.0000000000002116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A number of cellular microRNAs (miRNAs) have been identified to have the ability to inhibit HIV-1 replication. In this study, we examined the impact of combination antiretroviral therapy (cART) on the expression of HIV-1 restriction miRNAs in peripheral blood mononuclear cells of HIV-1-infected men who have sex with men (MSM). Compared with male healthy donors, HIV-infected MSM had significantly lower levels of 9 HIV-1 restriction miRNAs. The treatment of HIV-1-infected MSM with cART, however, failed to restore the levels of these miRNAs in peripheral blood mononuclear cells. These observations suggest that the suppression of the cellular restriction miRNAs by HIV-1 may attribute to the virus latency during cART.

引用

页数：5

共 18 条

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