The experiment is made in research center on winemaking technology, Bordeaux, French. Material is made from the merlot grape in Chateux Gudichaud vineyard. Adopting the same variety and winemaking technology, effect of different pectic enzyme on red wine is analyzed from many aspects in order to select the best pectic enzyme which is used in winemaking. As a result, effect of different pectic enzyme on the quality of wine is different. When Lafase He Grand Cru among pectic enzyme is emplying in winemaking, ratio of must is higher 5.8% than the average, at the same time, complexity and balance of wine in sensory quality is better than the others.