The Brain-Stomach Connection

被引：26
作者：
Folgueira, C. [1 ,3 ]
Seoane, L. M. [1 ,3 ]
Casanueva, F. F. [2 ,3 ]
机构：
[1] Complexo Hosp Univ Santiago CHUS SERGAS, Grp Fisiopatol Endocrina, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela, Spain
[2] CHUS SERGAS, Lab Endocrinol Mol & Celular, IDIS, ES-15706 Santiago De Compostela, Spain
[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Santiago De Compostela, Spain
来源：
HOW GUT AND BRAIN CONTROL METABOLISM | 2014年 / 42卷
关键词：
GASTRIC GHRELIN SECRETION; DEPENDENT MODULATION; MAMMALIAN TARGET; GROWTH-HORMONE; FOOD-INTAKE; NESFATIN-1; PEPTIDE; NEURONS; GUT;
D O I：
10.1159/000358316
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The stomach-brain connection has been revealed to be one of the most promising targets in treating obesity. The stomach plays a key role in the homeostatic mechanism implicating stomach-brain communication regulated under neural and hormonal control. The present review explores specific topics related to gut-brain interactions focus on the stomach-brain connection through the different known systems implied in energy balance control as ghrelin, and nesfatin. Moreover, novel mechanisms for energy balance regulation involving gastric-brain communication are described including the role of the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid gastric systems to modulate metabolism. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：83 / 92
页数：10
相关论文
共 25 条
[1]   Ghrelin acylation and metabolic control [J].
Al Massadi, O. ;
Tschoep, M. H. ;
Tong, J. .
PEPTIDES, 2011, 32 (11) :2301-2308
[2]   The Stomach as an Energy Homeostasis Regulating Center. An Approach for Obesity [J].
Al-Massadi, Omar ;
Pardo, Maria ;
Casanueva, Felipe F. ;
Seoane, Luisa M. .
RECENT PATENTS ON ENDOCRINE METABOLIC & IMMUNE DRUG DISCOVERY, 2010, 4 (01) :75-84
[3]   The vagus nerve, food intake and obesity [J].
Berthoud, Hans-Rudolf .
REGULATORY PEPTIDES, 2008, 149 (1-3) :15-25
[4]   Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin [J].
Burdyga, G ;
Lal, S ;
Varro, A ;
Dimaline, R ;
Thompson, DG ;
Dockray, GJ .
JOURNAL OF NEUROSCIENCE, 2004, 24 (11) :2708-2715
[5]   Endocannabinoids and the regulation of their levels in health and disease [J].
Di Marzo, Vincenzo ;
Petrosino, Stefania .
CURRENT OPINION IN LIPIDOLOGY, 2007, 18 (02) :129-140
[6]   Emerging Roles of NUCB2/Nesfatin-1 in the Metabolic Control of Reproduction [J].
Garcia-Galiano, David ;
Tena-Sempere, Manuel .
CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (39) :6966-6972
[7]  
Goebel-Stengel M, 2014, CURR PHARM DESIGN
[8]  
Gómez R, 2002, J NEUROSCI, V22, P9612
[9]   Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance [J].
Khamzina, L ;
Veilleux, A ;
Bergeron, S ;
Marette, A .
ENDOCRINOLOGY, 2005, 146 (03) :1473-1481
[10]  
Kirkham TC, 2001, NUTR RES REV, V14, P65, DOI [10.1079/095442201108729141, 10.1079/NRR200118]
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