Aspergillus has distinct fatty acid synthases for primary and secondary metabolism

被引：121
作者：
Brown, DW
Adams, TH
Keller, NP
机构：
[1] TEXAS A&M UNIV,DEPT PLANT PATHOL & MICROBIOL,COLLEGE STN,TX 77843
[2] TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 25期
关键词：
sterigmatocystin; aflatoxin; mycotoxin; polyketide; hexanoic acid;
D O I：
10.1073/pnas.93.25.14873
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Aspergillus nidulans contains two functionally distinct fatty acid synthases (FASs): one required for primary fatty acid metabolism (FAS) and the other required for secondary metabolism (sFAS). FAS mutants require long-chain fatty acids for growth, whereas sFAS mutants grow normally but cannot synthesize sterigmatocystin (ST), a carcinogenic secondary metabolite structurally and biosynthetically related to aflatoxin. sFAS mutants regain the ability to synthesize ST when provided with hexanoic acid, supporting the model that the ST polyketide synthase uses this short-chain fatty acid as a starter unit, The characterization of both the polyketide synthase and FAS may provide novel means for modifying secondary metabolites.
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收藏
页码：14873 / 14877
页数：5
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