SYNTHESIS AND EVALUATION OF CYTOTOXIC ACTIVITY OF NEW ACENAPHTHO TRIAZIN BENZAMIDE DERIVATIVES

被引：3
作者：
Sedeh, Somayeh Adibi [1 ,2 ]
Mohammadi, Mohammad Kazem [2 ]
Fereidoonnezhad, Masood [3 ,4 ]
Javid, Ali [5 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Khouzestan Sci & Res Branch, Ahvaz, Iran
[2] Islamic Azad Univ, Dept Chem, Ahvaz Branch, Ahvaz, Iran
[3] Ahvaz Jundishapur Univ Med Sci, Toxicol Res Ctr, Ahvaz, Iran
[4] Ahvaz Jundishapur Univ Med Sci, Sch Pharm, Dept Med Chem, Ahvaz, Iran
[5] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad, Razavi Khorasan, Iran
来源：
REVUE ROUMAINE DE CHIMIE | 2020年 / 65卷 / 05期
关键词：
acenaphtho triazine; synthesis; guanidine; cancer; 1,2,4-TRIAZINE DERIVATIVES; IDENTIFICATION; AGENTS;
D O I：
10.33224/rrch.2020.65.5.06
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this paper, we described the facile synthesis of new acenaphtho triazin benzamid derivatives. For this purpose, acenaphtho-(1, 2-e) (1, 2, 4) triazine-9-(8H) imine was prepared with the reaction of acenaphthoquinone and guanidine. Then, the reaction of this product with benzoyl chloride afforded the desired compounds in a good yield. The cytotoxicity of the synthesized compounds was also studied against human cancer cell lines including non-small cell lung (A549), ovarian (SKOV3) and breast (MCF-7) cancer cell lines, as well as normal lung cell line (MRC-5). Among them 5b, 5c and 5h showed moderate to good activity.
引用
收藏
页码：467 / 472
页数：6
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