Gene silencing -: Trans-histone regulatory pathway in chromatin

被引:396
作者
Briggs, SD [1 ]
Xiao, TJ
Sun, ZW
Caldwell, JA
Shabanowitz, J
Hunt, DF
Allis, CD
Strahl, BD
机构
[1] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA
[2] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
[3] Univ Virginia, Dept Chem, Charlottesville, VA 22908 USA
[4] Univ Virginia, Dept Pathol, Charlottesville, VA 22908 USA
关键词
All Open Access; Bronze;
D O I
10.1038/nature00970
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:498 / 498
页数:1
相关论文
共 11 条
[1]   Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae [J].
Briggs, SD ;
Bryk, M ;
Strahl, BD ;
Cheung, WL ;
Davie, JK ;
Dent, SYR ;
Winston, F ;
Allis, CD .
GENES & DEVELOPMENT, 2001, 15 (24) :3286-3295
[2]   Evidence that SET1, a factor required for methylation of histone H3, regulates rDNA silencing in S-cerevisiae by a sir2-independent mechanism [J].
Bryk, M ;
Briggs, SD ;
Strahl, BD ;
Curcio, MJ ;
Allis, CD ;
Winston, F .
CURRENT BIOLOGY, 2002, 12 (02) :165-170
[3]   Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold [J].
Dlakic, M .
TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (07) :405-407
[4]   Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain [J].
Feng, Q ;
Wang, HB ;
Ng, HH ;
Erdjument-Bromage, H ;
Tempst, P ;
Struhl, K ;
Zhang, Y .
CURRENT BIOLOGY, 2002, 12 (12) :1052-1058
[5]   Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome [J].
Kornberg, RD ;
Lorch, YL .
CELL, 1999, 98 (03) :285-294
[6]   Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association [J].
Ng, HH ;
Feng, Q ;
Wang, HB ;
Erdjument-Bromage, H ;
Tempst, P ;
Zhang, Y ;
Struhl, K .
GENES & DEVELOPMENT, 2002, 16 (12) :1518-1527
[7]   Rad6-dependent ubiquitination of histone H2B in yeast [J].
Robzyk, K ;
Recht, L ;
Osley, MA .
SCIENCE, 2000, 287 (5452) :501-504
[8]   The language of covalent histone modifications [J].
Strahl, BD ;
Allis, CD .
NATURE, 2000, 403 (6765) :41-45
[9]   Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression [J].
Strahl, BD ;
Grant, PA ;
Briggs, SD ;
Sun, ZW ;
Bone, JR ;
Caldwell, JA ;
Mollah, S ;
Cook, RG ;
Shabanowitz, J ;
Hunt, DF ;
Allis, CD .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (05) :1298-1306
[10]   Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast [J].
Sun, ZW ;
Allis, CD .
NATURE, 2002, 418 (6893) :104-108