Post-training administration of corticosterone enhances consolidation of contextual fear memory and hippocampal long-term potentiation in rats

被引:56
|
作者
Abrari, Kataneh [2 ]
Rashidy-Pour, Ali [1 ,4 ]
Semnanian, Saeed [3 ]
Fathollahi, Yaghoub [3 ]
机构
[1] Semnan Univ Med Sci, Sch Med, Lab Learning & Memory, Dept Physiol, Semnan, Iran
[2] Damghan Univ Basic Sci, Dept Biol, Damghan, Iran
[3] Tarbiat Modares Univ, Sch Med Sci, Dept Physiol, Tehran, Iran
[4] Semnan Univ Med Sci, Sch Med, Res Ctr Physiol, Semnan, Iran
关键词
Learning; Memory; Consolidation; Glucocorticoids; Contextual fear conditioning; Long-term potentiation; Hippocampus; GLUCOCORTICOID-INDUCED IMPAIRMENT; ADRENAL-STEROID RECEPTORS; BASOLATERAL AMYGDALA; CONDITIONED FEAR; NORADRENERGIC ACTIVATION; SYNAPTIC PLASTICITY; SPATIAL MEMORY; MESSENGER-RNA; RETRIEVAL; BRAIN;
D O I
10.1016/j.nlm.2008.10.008
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual fear conditioning task, rats received different doses of corticosterone. Testing 24 h later, it revealed that corticosterone enhanced memory consolidation in an inverted U shape as evidenced in increased freezing behavior of corticosterone-treated animals. The most effective dose was 3 mg/kg. In Experiment 2, LTP was examined in rats whose memory consolidation has been enhanced with corticosterone. The rats were trained as the above and received corticosterone (3 mg/kg) immediately after training. Immediately or up to one day after retention test, rats were anesthetized with urethane for LTIP experiments. For LTIP induction, three episodes of high frequency stimuli, 30 s apart, were delivered to the perforant path, each consisting of 10 stimuli at 250 Hz. LTP was assessed by measuring the increase in the initial slope of the population excitatory post-synaptic potentials and the amplitude of the population spikes. Data indicated that animals whose memory has been enhanced by corticosterone, also displayed enhanced hippocampal LTP. The above findings suggest that glucocorticoids may enhance contextual fear memory consolidation via enhancing hippocampal LTP. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:260 / 265
页数:6
相关论文
共 50 条
  • [21] PARALLEL AUGMENTATION OF HIPPOCAMPAL LONG-TERM POTENTIATION, THETA-RHYTHM, AND CONTEXTUAL FEAR CONDITIONING IN WATER-DEPRIVED RATS
    MAREN, S
    DECOLA, JP
    SWAIN, RA
    FANSELOW, MS
    THOMPSON, RF
    BEHAVIORAL NEUROSCIENCE, 1994, 108 (01) : 44 - 56
  • [22] POST-TRAINING HIPPOCAMPAL RHYTHMIC SLOW ACTIVITY (THETA) ELICITED BY SEPTAL STIMULATION IMPROVES MEMORY CONSOLIDATION IN RATS
    WETZEL, W
    OTT, T
    MATTHIES, H
    BEHAVIORAL BIOLOGY, 1977, 21 (01): : 32 - 40
  • [23] Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis
    Izumi, Yukitoshi
    O'Dell, Kazuko A.
    Zorumski, Charles F.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [24] mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination
    Khlaifia, Abdessattar
    Honore, Eve
    Artinian, Julien
    Laplante, Isabel
    Lacaille, Jean-Claude
    MOLECULAR BRAIN, 2022, 15 (01)
  • [25] mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination
    Abdessattar Khlaifia
    Eve Honoré
    Julien Artinian
    Isabel Laplante
    Jean-Claude Lacaille
    Molecular Brain, 15
  • [26] Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation
    Harburger, Lauren L.
    Pechenino, Angela S.
    Saadi, Altaf
    Frick, Karyn M.
    BEHAVIOURAL BRAIN RESEARCH, 2008, 194 (02) : 174 - 180
  • [27] Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory
    Hawk, Joshua D.
    Florian, Cedrick
    Abel, Ted
    LEARNING & MEMORY, 2011, 18 (06) : 367 - 370
  • [28] Post-training administration of a synthetic peptide ligand of the neural cell adhesion molecule, C3d, attenuates long-term expression of contextual fear conditioning
    Cambon, K
    Venero, C
    Berezin, V
    Bock, E
    Sandi, C
    NEUROSCIENCE, 2003, 122 (01) : 183 - 191
  • [29] Enhanced Hippocampal Long-Term Potentiation and Fear Memory in Btbd9 Mutant Mice
    DeAndrade, Mark P.
    Zhang, Li
    Doroodchi, Atbin
    Yokoi, Fumiaki
    Cheetham, Chad C.
    Chen, Huan-Xin
    Roper, Steven N.
    Sweatt, J. David
    Li, Yuqing
    PLOS ONE, 2012, 7 (04):
  • [30] Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats
    Chan, Jiangping
    Guan, Xin
    Ni, Yiling
    Luo, Lilu
    Yang, Liqiang
    Zhang, Pengyue
    Zhang, Jichuan
    Chen, Yanmei
    BEHAVIOURAL BRAIN RESEARCH, 2017, 321 : 61 - 68