Alteration of Brain Functional Networks in Early-Stage Parkinson's Disease: A Resting-State fMRI Study

被引:47
作者
Sang, Linqiong [1 ]
Zhang, Jiuquan [2 ]
Wang, Li [1 ]
Zhang, Jingna [1 ]
Zhang, Ye [1 ]
Li, Pengyue [1 ]
Wang, Jian [2 ]
Qiu, Mingguo [1 ]
机构
[1] Third Mil Med Univ, Coll Biomed Engn, Dept Med Imaging, Chongqing, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China
来源
PLOS ONE | 2015年 / 10卷 / 10期
基金
中国国家自然科学基金;
关键词
STRUCTURAL CORTICAL NETWORKS; GRAPH-THEORETICAL ANALYSIS; SMALL-WORLD; DRUG-NAIVE; CONNECTIVITY; ORGANIZATION; SCHIZOPHRENIA; DEPRESSION; FREQUENCY; NUCLEUS;
D O I
10.1371/journal.pone.0141815
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although alterations of topological organization have previously been reported in the brain functional network of Parkinson's disease (PD) patients, the topological properties of the brain network in early-stage PD patients who received antiparkinson treatment are largely unknown. This study sought to determine the topological characteristics of the large-scale functional network in early-stage PD patients. First, 26early-stage PD patients (Hoehn and Yahr stage: 1-2) and 30 age-matched normal controls were scanned using resting-state functional MRI. Subsequently, graph theoretical analysis was employed to investigate the abnormal topological configuration of the brain network in early-stage PD patients. We found that both the PD patient and control groups showed small-world properties in their functional brain networks. However, compared with the controls, the early-stage PD patients exhibited abnormal global properties, characterized by lower global efficiency. Moreover, the modular structure and the hub distribution were markedly altered in early-stage PD patients. Furthermore, PD patients exhibited increased nodal centrality, primarily in the bilateral pallidum, the inferior parietal lobule, and the medial superior frontal gyrus, and decreased nodal centrality in the caudate nucleus, the supplementary motor areas, the precentral gyrus, and the middle frontal gyrus. There were significant negative correlations between the Unified Parkinson Disease Rating Scale motor scores and nodal centralities of superior parietal gyrus. These results suggest that the topological organization of the brain functional network was altered in early-stage PD patients who received antiparkinson treatment, and we speculated that the antiparkinson treatment may affect the efficiency of the brain network to effectively relieve clinical symptoms of PD.
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页数:19
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