Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

被引：23

作者：

Buz, Pelin Turhan ^{[1
]}

Duman, Fatma Demir ^{[1
]}

Erkisa, Merve ^{[2
]}

Demirci, Gozde ^{[3
]}

Ari, Ferda ^{[4
]}

Ulukaya, Engin ^{[2
]}

Acar, Havva Yagci ^{[1
,5
]}

机构：

[1] Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey

[2] Istinye Univ, Sch Med, Dept Clin Biochem, TR-34010 Istanbul, Turkey

[3] Koc Univ, Grad Sch Mat Sci & Engn, TR-34450 Istanbul, Turkey

[4] Uludag Univ, Dept Biol, TR-16059 Bursa, Turkey

[5] Koc Univ, Surface Sci & Technol Ctr KUYTAM, TR-34450 Istanbul, Turkey

来源：

NANOMEDICINE | 2019年 / 14卷 / 08期

关键词：

Ag2S quantum dots; apoptosis; DNA damage; imaging; N-acetyl-L-cysteine (NAC); reactive oxygen species (ROS); DNA-DAMAGE; HIGHLY LUMINESCENT; ACETYLCYSTEINE NAC; OXIDATIVE STRESS; APOPTOSIS; GLUTATHIONE; INDUCTION; TOXICITY; GROWTH; NANOPARTICLES;

D O I：

10.2217/nnm-2018-0214

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.

引用

页码：969 / 988

页数：20

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