AChR-myasthenia gravis switching to double-seropositive several years after the onset

被引：21

作者：

Zouvelou, Vasiliki ^{[1
]}

Zisimopoulou, Paraskevi ^{[2
]}

Psimenou, Erasmia ^{[3
]}

Matsigkou, Eirini ^{[2
]}

Stamboulis, Eleftherios ^{[1
]}

Tzartos, Socrates J. ^{[2
,4
]}

机构：

[1] Univ Athens, Dept Neurol, Aeginit Hosp, Athens 11528, Greece

[2] Hellenic Pasteur Inst, Dept Biochem, Athens, Greece

[3] Alexandra Hosp, Renal Unit, Athens, Greece

[4] Tzartos NeuroDiagnost, Athens, Greece

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 267卷 / 1-2期

关键词：

Myasthenia gravis; Acetylcholine receptor; Muscle-specific kinase; Double seropositive; Cell-based assay; Biphasic course; ANTI-MUSK ANTIBODY; TYROSINE KINASE; THYMECTOMY;

D O I：

10.1016/j.jneuroim.2013.12.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report an early onset AChR-myasthenia gravis (MG) with biphasic clinical course. The clinical "switch" from AChR-MG to MuSK-MG emerged 16 years after the onset and 11 years after thymectomy. MuSK antibodies were detected only by cell-based assay and only upon clinical "switch", while AChR antibodies remained positive and at high titers during the whole disease course. Although the occurrence of AChR antibodies and MuSK antibodies in the same individual is rare, the re-assessment of the antibody status, using all available assays, is advisable when there is clinical indication. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：111 / 112

页数：2

共 15 条

[1] Long-term immunologic effects of thymectomy in patients with myasthenia gravis [J].

Gerli, R ;

Paganelli, R ;

Cossarizza, A ;

Muscat, C ;

Piccolo, G ;

Barbieri, D ;

Mariotti, S ;

Monti, D ;

Bistoni, O ;

Raiola, E ;

Venanzi, FM ;

Bertotto, A ;

Franceschi, C .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (05) :865-872

[2] ANTI-MuSK ANTIBODY MYASTHENIA GRAVIS: CLINICAL FINDINGS AND RESPONSE TO TREATMENT IN TWO LARGE COHORTS [J].

Guptill, Jeffrey T. ;

Sanders, Donald B. ;

Evoli, Amelia .

MUSCLE & NERVE, 2011, 44 (01) :36-40

[3] Juvenile seropositive myasthenia gravis with anti-MuSK antibody after thymectomy [J].

Kostera-Pruszczyk, Anna ;

Kwiecinski, Hubert .

JOURNAL OF NEUROLOGY, 2009, 256 (10) :1780-1781

[4] IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis [J].

Leite, Maria Isabel ;

Jacob, Saiju ;

Viegas, Stuart ;

Cossins, Judy ;

Clover, Linda ;

Morgan, B. Paul ;

Beeson, David ;

Willcox, Nick ;

Vincent, Angela .

BRAIN, 2008, 131 :1940-1952

[5] Distal myasthenia gravis [J].

Nations, SP ;

Wolfe, GI ;

Amato, AA ;

Jackson, CE ;

Bryan, WW ;

Barohn, RJ .

NEUROLOGY, 1999, 52 (03) :632-634

[6] DIAGNOSTIC SENSITIVITY OF THE LABORATORY TESTS IN MYASTHENIA-GRAVIS [J].

OH, SJ ;

KIM, DE ;

KURUOGLU, R ;

BRADLEY, RJ ;

DWYER, D .

MUSCLE & NERVE, 1992, 15 (06) :720-724

[7] Anti-MuSK- and anti-AChR-positive myasthenia gravis induced by d-penicillamine [J].

Poulas, Konstantinos ;

Koutsouraki, Euphrosyni ;

Kordas, Gregory ;

Kokla, Anna ;

Tzartos, Socrates J. .

JOURNAL OF NEUROIMMUNOLOGY, 2012, 250 (1-2) :94-98

[8] Clinically biphasic myasthenia gravis with both AChR and MuSK antibodies [J].

Rajakulendran, Sanjeev ;

Viegas, Stuart ;

Spillane, Jennifer ;

Howard, Robin S. .

JOURNAL OF NEUROLOGY, 2012, 259 (12) :2736-2739

[9] MuSK-antibody positive myasthenia gravis: Questions from the clinic [J].

Sanders, Donald B. ;

Juel, Vern C. .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 201 :85-89

[10] Anti-muSK antibody after thymectomy in a previously seropositive myasthenic child [J].

Saulat, Bilal ;

Maertens, Paul ;

Hamilton, William J. ;

Bassam, Bassam A. .

NEUROLOGY, 2007, 69 (08) :803-804

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