Modelling G-protein-coupled receptors for drug design

被引：196

作者：

Flower, DR ^{[1
]}

机构：

[1] ASTRA Charnwood, Dept Phys & Metab Sci, Loughborough LE11 5RH, Leics, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES | 1999年 / 1422卷 / 03期

关键词：

G-protein-coupled receptor; drug design; mutagenesis; molecular modeling; agonist; antagonist;

D O I：

10.1016/S0304-4157(99)00006-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The G-protein coupled receptors form a large and diverse multi-gene superfamily with many important physiological functions. As such, they have become important targets in pharmaceutical research. Molecular modelling and site-directed mutagenesis have played an important role in our increasing understanding of the structural basis of drug action at these receptors. Aspects of this understanding, how these techniques can be used within a drug-design programme, and remaining challenges for the future are reviewed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：207 / 234

页数：28

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