Continued complete remission without systemic therapy for isolated testicular relapse after bone marrow transplantation in a boy with acute lymphoblastic leukemia

被引：8

作者：

Kodama, Yuichi ^{[1
]}

Okamoto, Yasuhiro ^{[1
]}

Ijichi, Osamu ^{[1
]}

Shinkoda, Yuichi ^{[1
]}

Nishikawa, Takuro ^{[1
]}

Tanabe, Takayuki ^{[1
]}

Yoshioka, Takako ^{[2
]}

Tashiro, Yukie ^{[3
]}

Mougi, Hiroyuki ^{[4
]}

Kawano, Yoshifumi ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pediat, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Tumor Pathol, Kagoshima 8908520, Japan

[3] Imakiire Gen Hosp, Dept Pathol, Kagoshima, Japan

[4] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Blood Transfus Med, Kagoshima 8908520, Japan

来源：

PEDIATRIC TRANSPLANTATION | 2009年 / 13卷 / 06期

关键词：

acute lymphoblastic leukemia; isolated testicular relapse; bone marrow transplantation; local therapy; VERSUS-HOST DISEASE; TOTAL-BODY; CHILDREN; IRRADIATION; SURVIVAL; IMPACT;

D O I：

10.1111/j.1399-3046.2008.01023.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

ITR after BMT in cases of acute lymphoblastic leukemia is relatively rare. Treatment for ITR after BMT generally consists of a combination of local irradiation, orchiectomy, and systemic chemotherapy. However, the effectiveness of these modalities has not been established. Both irradiation and systemic chemotherapy including a second transplantation would result in additional toxicity. In this report we describe a boy with ITR 91 months after BMT who has remained in complete remission more than two yr after a unilateral orchiectomy. We did not treat this patient with systemic chemotherapy, as his ITR developed very late. Our experience suggests that orchiectomy alone is a reasonable option for very late ITR after BMT.

引用

页码：769 / 772

页数：4

共 12 条

[1]

ASHFORD RFU, 1983, LANCET, V23, P228

[2]

CAIRO M, 1982, AM J PEDIAT HEMATOL, V4, P41

[3]

CONTER V, 1989, HAEMATOLOGICA, V74, P507

[4] Extramedullary sites of leukemia relapse after transplant [J].

Cunningham, Isabel .

LEUKEMIA & LYMPHOMA, 2006, 47 (09) :1754-1767

[5] Graft-versus-leukaemia effect in children:: chronic GVHD has a significant impact on relapse and survival [J].

Jernberg, ÅG ;

Remberger, M ;

Ringdén, O ;

Winiarski, J .

BONE MARROW TRANSPLANTATION, 2003, 31 (03) :175-181

[6] Isolated testicular relapse after bone marrow transplant with total body irradiation and testicular boost in acute lymphoblastic leukemia [J].

Li, CK ;

Shing, MMK ;

Chik, KW ;

Kwan, WH ;

Lai, DH ;

Leung, TF ;

Yuen, PMP .

BONE MARROW TRANSPLANTATION, 1998, 22 (04) :397-399

[7] RELAPSE OF ACUTE-LEUKEMIA AFTER MARROW TRANSPLANTATION - NATURAL-HISTORY AND RESULTS OF SUBSEQUENT THERAPY [J].

MORTIMER, J ;

BLINDER, MA ;

SCHULMAN, S ;

APPELBAUM, FR ;

BUCKNER, CD ;

CLIFT, RA ;

SANDERS, JE ;

STORB, R ;

THOMAS, ED .

JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (01) :50-57

[8]

NACHMAN J, 1990, BLOOD, V75, P1051

[9] Comparison of the outcomes of allogeneic bone marrow transplantation from partially mismatched related donors, matched sibling donors, and matched unrelated donors in Japanese pediatric patients: A single center result [J].

Nagatoshi, Y ;

Kawano, Y ;

Okamura, J .

PEDIATRIC TRANSPLANTATION, 2004, 8 (03) :260-266

[10] The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation [J].

Quaranta, BP ;

Halperin, EC ;

Kurtzberg, J ;

Clough, R ;

Martin, PL .

CANCER, 2004, 101 (04) :845-850

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