Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis

被引：16

作者：

Almeida, Sintia ^{[1
]}

Sousa, Cassiana ^{[1
,2
]}

Abreu, Vincius

Diniz, Carlos ^{[1
]}

Dorneles, Elaine M. S. ^{[3
,4
]}

Lage, Andrey P. ^{[3
]}

Barh, Debmalya ^{[5
]}

Azevedo, Vasco ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Biol Sci, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Sao Paulo, Ctr Nucl Energy Agr, BR-13400970 Piracicaba, SP, Brazil

[3] Univ Fed Minas Gerais, Escola Vet, Belo Horizonte, MG, Brazil

[4] Univ Fed Lavras, Dept Med Vet, Lavras, MG, Brazil

[5] IIOAB, Ctr Genom & Appl Gene Technol, W Bengal, India

来源：

INTERNATIONAL JOURNAL OF GENOMICS | 2017年 / 2017卷

关键词：

COMPLETE GENOME SEQUENCE; DENITRIFYING PSEUDOMONAS-STUTZERI; ESCHERICHIA-COLI; CASEOUS-LYMPHADENITIS; ELECTRON-TRANSFER; NARJ CHAPERONE; STRAIN; SHEEP; INFECTION; IDENTIFICATION;

D O I：

10.1155/2017/9481756

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on the ability of nitrate reductase synthesis, Corynebacteriumpseudotuberculosis is classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources. Apart from these two biovars, some other strains are also able to carry out the reduction of nitrate. The enzymes that are involved in electron transport chain are also identified by in silico methods. Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and the C. pseudotuberculosis pathogenicity, virulence factors, and discovery of drug targets.

引用

页数：12

共 62 条

[1] Tellurite reductase activity of nitrate reductase is responsible for the basal resistance of Escherichia coli to tellurite [J].

Avazeri, C ;

Turner, RJ ;

Pommier, J ;

Weiner, JH ;

Giordano, G ;

Vermeglio, A .

MICROBIOLOGY-SGM, 1997, 143 :1181-1189

[2]

AYERS JL, 1977, J AM VET MED ASSOC, V171, P1251

[3] Survey of caseous lymphadenitis seroprevalence in British terminal sire sheep breeds [J].

Baird, G ;

Synge, B ;

Dercksen, D .

VETERINARY RECORD, 2004, 154 (16) :505-506

[4] Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis [J].

Baird, G. J. ;

Fontainet, M. C. .

JOURNAL OF COMPARATIVE PATHOLOGY, 2007, 137 (04) :179-210

[5] Genome Sequence of Corynebacterium pseudotuberculosis MB20 bv. equi Isolated from a Pectoral Abscess of an Oldenburg Horse in California [J].

Barauna, Rafael A. ;

Guimaraes, Luis C. ;

Veras, Adonney A. O. ;

de Sa, Pablo H. C. G. ;

Gracas, Diego A. ;

Pinheiro, Kenny C. ;

Silva, Andreia S. S. ;

Folador, Edson L. ;

Benevides, Leandro J. ;

Viana, Marcus V. C. ;

Carneiro, Adriana R. ;

Schneider, Maria P. C. ;

Spier, Sharon J. ;

Edman, Judy M. ;

Ramos, Rommel T. J. ;

Azevedo, Vasco ;

Silva, Artur .

GENOME ANNOUNCEMENTS, 2014, 2 (06)

[6] Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria [J].

Barth, Kenneth R. ;

Isabella, Vincent M. ;

Clark, Virginia L. .

MICROBIOLOGY-SGM, 2009, 155 :4093-4103

[7] Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A [J].

Bertero, MG ;

Rothery, RA ;

Palak, M ;

Hou, C ;

Lim, D ;

Blasco, F ;

Weiner, JH ;

Strynadka, NCJ .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :681-687

[8] RESPIRATORY NITRATE REDUCTASE FROM DENITRIFYING PSEUDOMONAS-STUTZERI, PURIFICATION, PROPERTIES AND TARGET OF PROTEOLYSIS [J].

BLUMLE, S ;

ZUMFT, WG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1057 (01) :102-108

[9] NITRATE REDUCTASES IN ESCHERICHIA-COLI [J].

BONNEFOY, V ;

DEMOSS, JA .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1994, 66 (1-3) :47-56

[10]

BROWN CC, 1986, AM J VET RES, V47, P1461

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