Lower Total Knee Arthroplasty Revision Risk Associated With Bisphosphonate Use, Even in Patients With Normal Bone Density

被引：33

作者：

Namba, Robert S. ^{[1
]}

Inacio, Maria C. S. ^{[2
]}

Cheetham, T. Craig ^{[3
]}

Dell, Richard M. ^{[4
]}

Paxton, Elizabeth W. ^{[2
]}

Khatod, Monti X. ^{[5
]}

机构：

[1] So Calif Permanente Med Grp, 6670 Alton Pkwy, Irvine, CA 92646 USA

[2] Kaiser Permanente Surg Outcomes & Anal, San Diego, CA USA

[3] Kaiser Permanente Res & Evaluat, Pasadena, CA USA

[4] So Calif Permanente Med Grp, Downey, CA USA

[5] So Calif Permanente Med Grp, Los Angeles, CA USA

来源：

JOURNAL OF ARTHROPLASTY | 2016年 / 31卷 / 02期

关键词：

total knee; bisphosphonates; revision; bone density; OSTEOPOROSIS DISEASE-MANAGEMENT; MINERAL DENSITY; JOINT ARTHROPLASTY; IMPLANT SURVIVAL; FRACTURES; METAANALYSIS; ALENDRONATE; VALUES; COHORT; FEMUR;

D O I：

10.1016/j.arth.2015.09.005

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: Bisphosphonates (BPs) are associated with lower total knee arthroplasty (TKA) revision risk, but the effect of bone mineral density has not been evaluated. Methods: A cohort of 34,116 primary TKA patients was evaluated with revision surgery and periprosthetic fractures as end points. BP usage was the exposure of interest. Bone quality (normal, osteopenia, and osteoporosis) and patient age (<65 vs >= 65 years) were evaluated as effect modifiers of risk estimates. Results: Of the patients, 19.6% were BP users. In BP users, 0.5% underwent an aseptic revision; and 0.6%, a periprosthetic fracture. In non-BP users, 1.6% underwent aseptic revision; and 0.1%, a periprosthetic fracture. Conclusion: Bisphosphonate use was associated with lower risk of revision in all bone quality categories in those older than 65 years. The risk of periprosthetic fractures was higher for patients on BP.

引用

页码：537 / 541

页数：5

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