Intrathecal cytokines in spinal cord schistosomiasis

被引：9
|
作者：
Abreu Ferrari, Teresa Cristina
Rocha Moreira, Paulo Roberto
Sampaio, Marcio Jose
da Cunha, Aloisio Sales
de Oliveira, Jose Teotonio
Gazzinelli, Giovanni
Correa-Oliveira, Rodrigo
机构：
[1] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Hosp Clin, Neurol Serv, BR-30130100 Belo Horizonte, MG, Brazil
[3] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Imunol Celular & Mol, BR-30190002 Belo Horizonte, MG, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 177卷 / 1-2期
关键词：
neuroschistosomiasis; spinal cord disease; cytokines; cerebrospinal fluid; Schistosoma mansoni;
D O I：
10.1016/j.jneuroim.2006.05.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1 beta, IL-4, IL-6 and IL-10 and low concentrations of TNF-alpha and IFN-gamma were observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-gamma was observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：136 / 141
页数：6
相关论文
共 50 条
  • [31] Cerebrospinal Fluid Inflammatory Cytokines and Biomarkers of Injury Severity in Acute Human Spinal Cord Injury
    Kwon, Brian K.
    Stammers, Anthea M. T.
    Belanger, Lise M.
    Bernardo, Arlene
    Chan, Donna
    Bishop, Carole M.
    Slobogean, Gerard P.
    Zhang, Hongbin
    Umedaly, Hamed
    Giffin, Mitch
    Street, John
    Boyd, Michael C.
    Paquette, Scott J.
    Fisher, Charles G.
    Dvorak, Marcel F.
    JOURNAL OF NEUROTRAUMA, 2010, 27 (04) : 669 - 682
  • [32] Spinal schistosomiasis masquerading as an intramedullary tumor
    Mansour, Moustafa A.
    Bayoumi, Mahmoud
    Hamdi, Abdou
    Moawad, Yehia
    Ayad, Ahmad A.
    Ahmadi, Zarina
    IDCASES, 2023, 32
  • [33] Cerebrospinal fluid in the diagnosis of spinal schistosomiasis
    Tesser, E
    dos Reis, MDLAA
    Borelli, P
    Matas, SLA
    dos Reis, JB
    ARQUIVOS DE NEURO-PSIQUIATRIA, 2005, 63 (3A) : 661 - 665
  • [34] Effects of Intrathecal Injection of the Conditioned Medium from Bone Marrow Stromal Cells on Spinal Cord Injury in Rats
    Kanekiyo, Kenji
    Wakabayashi, Tamami
    Nakano, Norihiko
    Yamada, Yoshihiro
    Tamachi, Masahiro
    Suzuki, Yoshihisa
    Fukushima, Masatoshi
    Saito, Fukuki
    Abe, Seiya
    Tsukagoshi, Chihiro
    Miyamoto, Chimi
    Ide, Chizuka
    JOURNAL OF NEUROTRAUMA, 2018, 35 (03) : 521 - 532
  • [35] Proteomic Modulation in the Dorsal Spinal Cord Following Spinal Cord Stimulation Therapy in anIn VivoNeuropathic Pain Model
    Tilley, Dana M.
    Lietz, Christopher B.
    Cedeno, David L.
    Kelley, Courtney A.
    Li, Lingjun
    Vallejo, Ricardo
    NEUROMODULATION, 2021, 24 (01): : 22 - 32
  • [36] Spinal cord Schistosomiasis: A child's case with an unsatisfactory outcome that mimicked an intramedullary neoplasm. A rare case report
    Mohamed, Abdikarin Ahmed
    Mengistu, Mihret Gebrehiwot
    Haftu, Hansa
    Mustefa, Mohammed
    Yusuf, Abdisalam Abdullahi
    ANNALS OF MEDICINE AND SURGERY, 2022, 82
  • [37] Immunological and Biochemical Interplay between Cytokines, Oxidative Stress and Schistosomiasis
    Masamba, Priscilla
    Kappo, Abidemi Paul
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
  • [38] Fetal and Perinatal Expression Profiles of Proinflammatory Cytokines in the Neuroplacodes of Rats with Myelomeningoceles: A Contribution to the Understanding of Secondary Spinal Cord Injury in Open Spinal Dysraphism
    Cohrs, Gesa
    Blumenroether, Ann-Kathrin
    Suerie, Jan-Philip
    Synowitz, Michael
    Held-Feindt, Janka
    Knerlich-Lukoschus, Friederike
    JOURNAL OF NEUROTRAUMA, 2021, 38 (24) : 3376 - 3392
  • [39] Interleukin-6 in Spinal Cord Injury: Could Immunomodulation Replace Immunosuppression in the Management of Acute Traumatic Spinal Cord Injuries?
    Shipman, Hank
    Monsour, Molly
    Foley, Madeline M.
    Marbacher, Serge
    Croci, Davide M.
    Bisson, Erica F.
    JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, 2024, 85 (06) : 602 - 609
  • [40] Plasma Cytokines Level and Spinal Cord MRI Predict Clinical Outcome in a Rat Glial Scar Cryoinjury Model
    Telegin, Georgii B.
    Chernov, Aleksandr S.
    Minakov, Alexey N.
    Rodionov, Maksim, V
    Kazakov, Vitaly A.
    Palikov, Viktor A.
    Balmasova, Irina P.
    Asyutin, Dmitry S.
    Poluektov, Yuri M.
    Konovalov, Nikolay A.
    Kudriaeva, Anna A.
    Spallone, Aldo
    Gabibov, Alexander G.
    Belogurov, Alexey A. Jr Jr
    BIOMEDICINES, 2022, 10 (10)
12345