共 44 条
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists
被引:13
作者:

Chen, Sheng-Ren
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Ke, Yi-Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Yeh, Teng-Kuang
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Lin, Shu-Yu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Ou, Li-Chin
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Chen, Shu-Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Chang, Wan-Ting
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Chang, Hsiao-Fu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Wu, Zih-Huei
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Hsieh, Chih-Chien
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Law, Ping-Yee
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Loh, Horace H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Shih, Chuan
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Lai, Yiu-Kay
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Tsing Hua Univ, Inst Biotechnol, Hsinchu, Taiwan
Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Yeh, Shiu-Hwa
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan
Taipei Med Univ, PhD Program Neural Regenerat Med, Taipei 110, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan

Ueng, Shau-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan
机构:
[1] Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Jhunan 35053, Miaoli County, Taiwan
[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA
[3] Natl Tsing Hua Univ, Inst Biotechnol, Hsinchu, Taiwan
[4] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan
[5] Taipei Med Univ, PhD Program Neural Regenerat Med, Taipei 110, Taiwan
关键词:
mu-opioid receptor agonist;
kappa-opioid receptor agonist;
Structure-activity relationship;
Blood-brain barrier;
Penetration;
Anti-nociceptive effects;
Tail-flick test;
BIOLOGICAL EVALUATION;
RHESUS-MONKEYS;
MU;
COCAINE;
EXPRESSION;
MORPHINE;
LIGANDS;
CLONING;
DESIGN;
BRAIN;
D O I:
10.1016/j.ejmech.2016.09.003
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
mu-Opioid receptor (MOR) agonists are analgesics used clinically for the treatment of moderate to severe pain, but their use is associated with severe adverse effects such as respiratory depression, constipation, tolerance, dependence, and rewarding effects. In this study, we identified N-((2-[(4-bromo-2trifluoromethoxyphenyl)sulfony1]-1,2,3,4-tetrahydro-1-isoquinolinyl}methyl)cyclohexanecarboxamide (1) as a novel opioid receptor agonist by high-throughput screening. Structural modifications made to 1 to improve potency and blood-brain-barrier (BBB) penetration resulted in compounds 45 and 46. Compound 45 was a potent MOR/KOR (kappa-opioid receptor) agonist, and compound 46 was a potent MOR and medium KOR agonist. Both 45 and 46 demonstrated a significant anti-nociceptive effect in a tail-flick test performed in wild type (WT) B6 mice. The ED50 value of 46 was 1.059 mg/kg, and the brain concentrations of 45 and 46 were 7424 and 11696 ng/g, respectively. Accordingly, compounds 45 and 46 are proposed for lead optimization and in vivo disease-related pain studies. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:202 / 217
页数:16
相关论文
共 44 条
[1]
DISTRIBUTION AND PHYSIOLOGICAL SIGNIFICANCE OF OPIOID RECEPTORS IN THE BRAIN
[J].
ATWEH, SF
;
KUHAR, MJ
.
BRITISH MEDICAL BULLETIN,
1983, 39 (01)
:47-&

ATWEH, SF
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

KUHAR, MJ
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205
[2]
Trafficking of central opioid receptors and descending pain inhibition
[J].
Bie, Bihua
;
Pan, Zhizhong Z.
.
MOLECULAR PAIN,
2007, 3

Bie, Bihua
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA

Pan, Zhizhong Z.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA Univ Texas Houston, MD Anderson Canc Ctr, Dept Anesthesiol & Pain Med, Houston, TX 77030 USA
[3]
Effects of mixed-action κ/μ opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys
[J].
Bowen, CA
;
Negus, SS
;
Zong, RS
;
Neumeyer, JL
;
Bidlack, JM
;
Mello, NK
.
NEUROPSYCHOPHARMACOLOGY,
2003, 28 (06)
:1125-1139

Bowen, CA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

Negus, SS
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

Zong, RS
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

Neumeyer, JL
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

Bidlack, JM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA

Mello, NK
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, McLean Hosp, Sch Med, Alcohol & Drug Abuse Res Ctr, Belmont, MA 02478 USA
[4]
CHARMM: The Biomolecular Simulation Program
[J].
Brooks, B. R.
;
Brooks, C. L., III
;
Mackerell, A. D., Jr.
;
Nilsson, L.
;
Petrella, R. J.
;
Roux, B.
;
Won, Y.
;
Archontis, G.
;
Bartels, C.
;
Boresch, S.
;
Caflisch, A.
;
Caves, L.
;
Cui, Q.
;
Dinner, A. R.
;
Feig, M.
;
Fischer, S.
;
Gao, J.
;
Hodoscek, M.
;
Im, W.
;
Kuczera, K.
;
Lazaridis, T.
;
Ma, J.
;
Ovchinnikov, V.
;
Paci, E.
;
Pastor, R. W.
;
Post, C. B.
;
Pu, J. Z.
;
Schaefer, M.
;
Tidor, B.
;
Venable, R. M.
;
Woodcock, H. L.
;
Wu, X.
;
Yang, W.
;
York, D. M.
;
Karplus, M.
.
JOURNAL OF COMPUTATIONAL CHEMISTRY,
2009, 30 (10)
:1545-1614

Brooks, B. R.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Brooks, C. L., III
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USA NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Mackerell, A. D., Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Nilsson, L.
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Biosci & Nutr, SE-14157 Huddinge, Sweden NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Petrella, R. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

论文数: 引用数:
h-index:
机构:

Won, Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Hanyang Univ, Dept Chem, Seoul 133792, South Korea NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Archontis, G.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Bartels, C.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Boresch, S.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Caflisch, A.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Caves, L.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Cui, Q.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Dinner, A. R.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Feig, M.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Fischer, S.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Gao, J.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Hodoscek, M.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Im, W.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Kuczera, K.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Lazaridis, T.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Ma, J.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Ovchinnikov, V.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Paci, E.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Pastor, R. W.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Post, C. B.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Pu, J. Z.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Schaefer, M.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Tidor, B.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Venable, R. M.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Woodcock, H. L.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Wu, X.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Yang, W.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

York, D. M.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA

Karplus, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Univ Strasbourg, ISIS, Lab Chim Biophys, F-67000 Strasbourg, France NHLBI, Lab Computat Biol, NIH, Bethesda, MD 20892 USA
[5]
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
[J].
Bruchas, M. R.
;
Land, B. B.
;
Chavkin, C.
.
BRAIN RESEARCH,
2010, 1314
:44-55

Bruchas, M. R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

Land, B. B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
Univ Washington, Program Neurobiol & Behav, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

Chavkin, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
Univ Washington, Program Neurobiol & Behav, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
[6]
Mixed κ/μ Opioid Receptor Agonists: The 6β-Naltrexamines
[J].
Cami-Kobeci, Gerta
;
Neal, Adrian P.
;
Bradbury, Faye A.
;
Purington, Lauren C.
;
Aceto, Mario D.
;
Harris, Louis S.
;
Lewis, John W.
;
Traynor, John R.
;
Husbands, Stephen M.
.
JOURNAL OF MEDICINAL CHEMISTRY,
2009, 52 (06)
:1546-1552

Cami-Kobeci, Gerta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Neal, Adrian P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Bradbury, Faye A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Purington, Lauren C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Aceto, Mario D.
论文数: 0 引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA USA Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Harris, Louis S.
论文数: 0 引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA USA Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Lewis, John W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Traynor, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

Husbands, Stephen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
[7]
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists
[J].
Cheng, Ming-Fu
;
Ou, Li-Chin
;
Chen, Shu-Chun
;
Chang, Wan-Ting
;
Law, Ping-Yee
;
Loh, Horace H.
;
Chao, Yu-Sheng
;
Shih, Chuan
;
Yeh, Shiu-Hwa
;
Ueng, Shau-Hua
.
BIOORGANIC & MEDICINAL CHEMISTRY,
2014, 22 (17)
:4694-4703

Cheng, Ming-Fu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Ou, Li-Chin
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Chen, Shu-Chun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Chang, Wan-Ting
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Law, Ping-Yee
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Loh, Horace H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Chao, Yu-Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Shih, Chuan
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Yeh, Shiu-Hwa
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan

Ueng, Shau-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan
[8]
Morphine-induced μ-opioid receptor rapid desensitization is independent of receptor phosphorylation and β-arrestins
[J].
Chu, Ji
;
Zheng, Hui
;
Loh, Horace H.
;
Law, Ping-Yee
.
CELLULAR SIGNALLING,
2008, 20 (09)
:1616-1624

Chu, Ji
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA

Zheng, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA

Loh, Horace H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA

Law, Ping-Yee
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA
[9]
THE UP-AND-DOWN METHOD FOR THE DETERMINATION OF NOCICEPTIVE THRESHOLDS IN RATS
[J].
CROCKER, AD
;
RUSSELL, RW
.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,
1984, 21 (01)
:133-136

CROCKER, AD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024

RUSSELL, RW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024
[10]
Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives
[J].
Deekonda, Srinivas
;
Wugalter, Lauren
;
Rankin, David
;
Largent-Milnes, Tally M.
;
Davis, Peg
;
Wang, Yue
;
Bassirirad, Neemah M.
;
Lai, Josephine
;
Kulkarni, Vinod
;
Vanderah, Todd W.
;
Porreca, Frank
;
Hruby, Victor J.
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
2015, 25 (20)
:4683-4688

Deekonda, Srinivas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Wugalter, Lauren
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Rankin, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Largent-Milnes, Tally M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Davis, Peg
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Wang, Yue
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Bassirirad, Neemah M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Lai, Josephine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Kulkarni, Vinod
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

Vanderah, Todd W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

论文数: 引用数:
h-index:
机构:

Hruby, Victor J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA