Role of genotype in the cycle of violence in maltreated children

被引：2615

作者：

Caspi, A

McClay, J

Moffitt, TE ^{[1
]}

Mill, J

Martin, J

Craig, IW

Taylor, A

Poulton, R

机构：

[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, MRC, London SE5 8AF, England

[2] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA

[3] Univ Otago, Dunedin Sch Med, Dunedin, New Zealand

来源：

SCIENCE | 2002年 / 297卷 / 5582期

关键词：

D O I：

10.1126/science.1072290

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults.

引用

页码：851 / 854

页数：5

共 57 条

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