Metallopharmaceuticals in Therapy - A New Horizon for Scientific Research

被引：26

作者：

Chylewska, Agnieszka ^{[1
]}

Biedulska, Malgorzata ^{[1
]}

Sumczynski, Przemyslaw ^{[1
]}

Makowski, Mariusz ^{[1
]}

机构：

[1] Univ Gdansk, Fac Chem, Lab Intermol Interact, Wita Stwosza 63, PL-80308 Gdansk, Poland

来源：

CURRENT MEDICINAL CHEMISTRY | 2018年 / 25卷 / 15期

关键词：

Metallopharmaceuticals; coordination compounds; cancer therapeutic drugs; antimicrobial agents; medical diagnosis; mechanisms of activities; TRANSITION-METAL-COMPLEXES; NF-KAPPA-B; CLIOQUINOL-RUTHENIUM COMPLEX; VIVO ANTITUMOR-ACTIVITY; MIXED-LIGAND COMPLEXES; PROGRAMMED CELL-DEATH; SCHIFF-BASE LIGANDS; IN-VITRO EVALUATION; DNA-BINDING; BIOLOGICAL-ACTIVITY;

D O I：

10.2174/0929867325666171206102501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coordination chemistry offers much scope for the design of novel and therapeutic agents, including metallopharmaceuticals. The widespread use of metal complexes as effective pharmaceuticals, e.g. cancer therapeutic, anti-inflammatory, antidiabetic drugs or antimicrobial and diagnostic agents, demonstrates that the cytotoxicity of metal ions can be finely controlled via the appropriate choice of ligands. The successful targeting of radioisotopes again depends on the ligand design and metal oxidation state. The complexes of platinum, ruthenium, cobalt, copper and other d-block metal ions have been used in medicine for a long time but only recent advances have been made in understanding the molecular basis of mechanism of their action. Due to the above mentioned purpose, we decided to prepare a detailed description of target-based research, directed towards a design and application possibilities, with the known mechanisms of action of metal ion complexes in the broad sense of therapy definition. The review also covers the progress, limitations and challenges of the above-mentioned approaches and emphasizes the advantages of well known and new metallopharmaceuticals in medicine and pharmacy.

引用

页码：1729 / 1791

页数：63

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