The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study

被引：19

作者：

Ebina, Yasuhiko ^{[1
]}

Minematsu, Toshio ^{[2
]}

Sonoyama, Ayako ^{[3
]}

Morioka, Ichiro ^{[4
]}

Inoue, Naoki ^{[5
]}

Tairaku, Shinya ^{[3
]}

Nagamata, Satoshi ^{[3
]}

Tanimura, Kenji ^{[3
]}

Morizane, Mayumi ^{[3
]}

Deguchi, Masashi ^{[3
]}

Yamada, Hideto ^{[3
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Obstet & Gynecol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Aisenkai Nichinan Hosp, Res Ctr Dis Control, Miyazaki, Japan

[3] Kobe Univ, Grad Sch Med, Dept Obstet & Gynecol, Kobe, Hyogo 6500017, Japan

[4] Kobe Univ, Grad Sch Med, Dept Pediat, Kobe, Hyogo 6500017, Japan

[5] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

来源：

JOURNAL OF PERINATAL MEDICINE | 2014年 / 42卷 / 06期

关键词：

Congenital infection; cytomegalovirus; IgG avidity; PRIMARY CMV INFECTION; PREGNANT-WOMEN; DIAGNOSIS;

D O I：

10.1515/jpm-2013-0333

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. Objectives: To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection. Study design: The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study. Results: Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in < 28 weeks of gestation. Conclusion: The IgG avidity measurement with a cutoff value of < 40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in < 28 weeks of gestation.

引用

页码：755 / 759

页数：5

共 13 条

[1] DIFFERENTIATION OF PRIMARY CYTOMEGALOVIRUS-INFECTION FROM REACTIVATION USING THE UREA DENATURATION TEST FOR MEASURING ANTIBODY AVIDITY [J].