The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation

被引：110

作者：

Bruno, Stefania ^{[1
]}

Deregibus, Maria Chiara ^{[2
]}

Camussi, Giovanni ^{[2
]}

机构：

[1] Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[2] Univ Turin, Dept Med Sci, Turin, Italy

来源：

IMMUNOLOGY LETTERS | 2015年 / 168卷 / 02期

关键词：

Mesenchymal stem cells; Immune-modulation; Soluble factors; Extracellular vesicles; SUPPRESS T-LYMPHOCYTE; STEM-CELLS; MEMBRANE-VESICLES; DENDRITIC CELLS; HORIZONTAL TRANSFER; IMMUNE-RESPONSE; MESSENGER-RNA; B-LYMPHOCYTES; IN-VITRO; EXOSOMES;

D O I：

10.1016/j.imlet.2015.06.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stromal cells (MSCs) inhibit natural killer cell proliferation and activity, suppress T lymphocyte proliferation, dendritic cells maturation and B lymphocyte proliferation and activation. Moreover, MSCs may induce regulatory T cells. Several factors released from MSCs have been implicated in their immune-modulatory properties. These include soluble factors such as interleukins 6 and 10, prostaglandin E2, hepatocyte growth factor, indoleamine 2,3-dioxygenase, nitric oxide, transforming growth factor beta 1, human leukocyte antigen and extracellular vesicles. These vesicles released from cells have been characterized as a new mechanism of cell-to-cell communication and emerged as mediators of the MSC-immune-modulatory effects. In this review we focused our attention on the extracellular vesicles as paracrine mediators of MSC immune-modulation. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：154 / 158

页数：5

共 71 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2] Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T gondii infection [J].

Aline, F ;

Bout, D ;

Amigorena, S ;

Roingeard, P ;

Dimier-Poisson, I .

INFECTION AND IMMUNITY, 2004, 72 (07) :4127-4137

[3] Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: A novel mechanism for phenotype modulation [J].

Aliotta, Jason M. ;

Sanchez-Guijo, Fermin M. ;

Dooner, Gerri J. ;

Johnson, Kevin W. ;

Dooner, Mark S. ;

Greer, Kenneth A. ;

Greer, Deborah ;

Pimentel, Jeffrey ;

Kolankiewicz, Lutz M. ;

Puente, Napoleon ;

Faradyan, Sam ;

Ferland, Paulette ;

Bearer, Elaine L. ;

Passero, Michael A. ;

Adedi, Mehrdad ;

Colvin, Geralt A. ;

Quesenberry, Peter J. .

STEM CELLS, 2007, 25 (09) :2245-2256

[4] Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles [J].

Andreola, G ;

Rivoltini, L ;

Castelli, C ;

Huber, V ;

Perego, P ;

Deho, P ;

Squarcina, P ;

Accornero, P ;

Lozupone, F ;

Lugini, L ;

Stringaro, A ;

Molinari, A ;

Arancia, G ;

Gentile, M ;

Parmiani, G ;

Fais, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (10) :1303-1316

[5] Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes [J].

Ashiru, Omodele ;

Boutet, Philippe ;

Fernandez-Messina, Lola ;

Agueera-Gonzalez, Sonia ;

Skepper, Jeremy N. ;

Vales-Gomez, Mar ;

Reyburn, Hugh T. .

CANCER RESEARCH, 2010, 70 (02) :481-489

[6] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[7] Exosomes released from infected macrophages contain mycobacterium avium glycopeptidolipids and are proinflammatory [J].

Bhatnagar, Sanchita ;

Schorey, Jeffrey S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (35) :25779-25789

[8] Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells [J].

Blazquez, Rebeca ;

Sanchez-Margallo Francisco, Miguel ;

de la Rosa, Olga ;

Dalemans, Wilfried ;

Alvarez, Veronica ;

Tarazona, Raquel ;

Casado Javier, G. .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[9] Role of mesenchymal stem cell-derived microvesicles in tissue repair [J].

Bruno, Stefania ;

Camussi, Giovanni .

PEDIATRIC NEPHROLOGY, 2013, 28 (12) :2249-2254

[10] Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth [J].

Bruno, Stefania ;

Collino, Federica ;

Deregibus, Maria Chiara ;

Grange, Cristina ;

Tetta, Ciro ;

Camussi, Giovanni .

STEM CELLS AND DEVELOPMENT, 2013, 22 (05) :758-771

← 1 2 3 4 5 6 7 8 →