Eosinophilic Esophagitis Emerging Therapies and Future Perspectives

被引：7

作者：

Straumann, Alex ^{[1
,2
]}

机构：

[1] Swiss EoE Clin, CH-4600 Olten, Switzerland

[2] Swiss EoE Res Network, CH-4600 Olten, Switzerland

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 02期

关键词：

CRTH2; antagonists; Disease monitoring; Eosinophilic esophagitis; Esophageal distensibility; Esophageal string test; IL-4; antagonist; IL-13; CONSENSUS RECOMMENDATIONS; DOUBLE-BLIND; CHILDREN; ADULTS; FLUTICASONE; ELIMINATION; BUDESONIDE; ANTAGONIST; REMISSION; DIAGNOSIS;

D O I：

10.1016/j.gtc.2014.02.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Twenty years have passed since eosinophilic esophagitis was first recognized as a new and distinct entity. Current treatment modalities for eosinophilic esophagitis include the "3 Ds": drugs, allergen avoidance with diet, and esophageal dilation. Drugs entail the limitation that only corticosteroids have a proven efficacy; most other compounds evoke only a minimal effect. Diets must be maintained continuously and they interfere markedly with the quality of life, possibly even involving some risk of malnutrition. A greater understanding of the immunopathogenesis, natural history, and disease spectrum will inevitably lead to improved therapeutic outcomes for this emerging entity.

引用

页码：385 / +

页数：12

共 39 条

[1] Swallowed Fluticasone Improves Histologic but Not Symptomatic Response of Adults With Eosinophilic Esophagitis [J].

Alexander, Jeffrey A. ;

Jung, Kee Wook ;

Arora, Amindra S. ;

Enders, Felicity ;

Katzka, David A. ;

Kephardt, Gail M. ;

Kita, Hirohito ;

Kryzer, Lori A. ;

Romero, Yvonne ;

Smyrk, Thomas C. ;

Talley, Nicholas J. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2012, 10 (07) :742-+

[2] An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis [J].

Assa'ad, Amal H. ;

Gupta, Sandeep K. ;

Collins, Margaret H. ;

Thomson, Mike ;

Heath, Amy T. ;

Smith, Deborah A. ;

Perschy, Teresa L. ;

Jurgensen, Cynthia H. ;

Ortega, Hector G. ;

Aceves, Seema S. .

GASTROENTEROLOGY, 2011, 141 (05) :1593-1604

[3] ESOPHAGEAL EOSINOPHILIA WITH DYSPHAGIA - A DISTINCT CLINICOPATHOLOGICAL SYNDROME [J].

ATTWOOD, SEA ;

SMYRK, TC ;

DEMEESTER, TR ;

JONES, JB .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (01) :109-116

[4] Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis [J].

Blanchard, C ;

Wang, N ;

Stringer, KF ;

Mishra, A ;

Fulkerson, PC ;

Abonia, JP ;

Jameson, SC ;

Kirby, C ;

Konikoff, MR ;

Collins, MH ;

Cohen, MB ;

Akers, R ;

Hogan, SP ;

Assa'ad, AH ;

Putnam, PE ;

Aronow, BJ ;

Rothenberg, ME .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (02) :536-547

[5] Oral Viscous Budesonide Is Effective in Children With Eosinophilic Esophagitis in a Randomized, Placebo-Controlled Trial [J].

Dohil, Ranjan ;

Newbury, Robert ;

Fox, Lyman ;

Bastian, John ;

Aceves, Seema .

GASTROENTEROLOGY, 2010, 139 (02) :418-429

[6] Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes [J].

Forssmann, U ;

Uguccioni, M ;

Loetscher, P ;

Dahinden, CA ;

Langen, H ;

Thelen, M ;

Baggiolini, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (12) :2171-2176

[7] Eosinophilic esophagitis in children and adults: A systematic review and consensus recommendations for diagnosis and treatment [J].

Furuta, Glenn T. ;

Liacouras, Chris A. ;

Collins, Margaret H. ;

Gupta, Sandeep K. ;

Justinich, Chris ;

Putnam, Phil E. ;

Bonis, Peter ;

Hassall, Eric ;

Straumann, Alex ;

Rothenberg, Marc E. .

GASTROENTEROLOGY, 2007, 133 (04) :1342-1363

[8] The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis [J].

Furuta, Glenn T. ;

Kagalwalla, Amir F. ;

Lee, James J. ;

Alumkal, Preeth ;

Maybruck, Brian T. ;

Fillon, Sophie ;

Masterson, Joanne C. ;

Ochkur, Sergei ;

Protheroe, Cheryl ;

Moore, Wendy ;

Pan, Zhaoxing ;

Amsden, Katie ;

Robinson, Zachary ;

Capocelli, Kelley ;

Mukkada, Vince ;

Atkins, Dan ;

Fleischer, David ;

Hosford, Lindsay ;

Kwatia, Mark A. ;

Schroeder, Shauna ;

Kelly, Caleb ;

Lovell, Mark ;

Melin-Aldana, Hector ;

Ackerman, Steven J. .

GUT, 2013, 62 (10) :1395-1405

[9] Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia [J].

GarciaZepeda, EA ;

Rothenberg, ME ;

Ownbey, RT ;

Celestin, J ;

Leder, P ;

Luster, AD .

NATURE MEDICINE, 1996, 2 (04) :449-456

[10] Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors [J].

Gonsalves, Nirmala ;

Yang, Guang-Yu ;

Doerfler, Bethany ;

Ritz, Sally ;

Ditto, Anne M. ;

Hirano, Ikuo .

GASTROENTEROLOGY, 2012, 142 (07) :1451-+

← 1 2 3 4 →