Presynaptic Calcium Channels

被引：35
作者：
Mochida, Sumiko [1 ]
机构：
[1] Tokyo Med Univ, Dept Physiol, Tokyo 1608402, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期
关键词：
Ca2+ channels; synaptic transmission; G-proteins; synaptic proteins; Ca2+ binding proteins; G-PROTEIN MODULATION; VOLTAGE-DEPENDENT MODULATION; RAT SYMPATHETIC NEURONS; LONG-TERM POTENTIATION; N-TYPE CHANNELS; CA2+ CHANNELS; CA(V)2.1 CHANNELS; TRANSMITTER RELEASE; KINASE-II; SYNAPTIC PLASTICITY;
D O I：
10.3390/ijms20092217
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Presynaptic Ca2+ entry occurs through voltage-gated Ca2+ (Ca-V) channels which are activated by membrane depolarization. Depolarization accompanies neuronal firing and elevation of Ca2+ triggers neurotransmitter release from synaptic vesicles. For synchronization of efficient neurotransmitter release, synaptic vesicles are targeted by presynaptic Ca2+ channels forming a large signaling complex in the active zone. The presynaptic Ca(V)2 channel gene family (comprising Ca(V)2.1, Ca(V)2.2, and Ca(V)2.3 isoforms) encode the pore-forming 1 subunit. The cytoplasmic regions are responsible for channel modulation by interacting with regulatory proteins. This article overviews modulation of the activity of Ca(V)2.1 and Ca(V)2.2 channels in the control of synaptic strength and presynaptic plasticity.
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页数：19
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