CANCER The nuances of therapy

被引:49
作者
Ellis, Lee M. [1 ,2 ]
Reardon, David A. [3 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumour Ctr, Durham, NC 27710 USA
关键词
D O I
10.1038/458290a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study.
引用
收藏
页码:290 / 292
页数:3
相关论文
共 12 条
  • [1] HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Du, Rose
    Lu, Kan V.
    Petritsch, Claudia
    Liu, Patty
    Ganss, Ruth
    Passegue, Emmanuelle
    Song, Hanqiu
    VandenBerg, Scott
    Johnson, Randall S.
    Werb, Zena
    Bergers, Gabriele
    [J]. CANCER CELL, 2008, 13 (03) : 206 - 220
  • [2] Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
    Ebos, John M. L.
    Lee, Christina R.
    Christensen, James G.
    Mutsaers, Anthony J.
    Kerbel, Robert S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) : 17069 - 17074
  • [3] Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
    Ebos, John M. L.
    Lee, Christina R.
    Cruz-Munoz, William
    Bjarnason, Georg A.
    Christensen, James G.
    Kerbel, Robert S.
    [J]. CANCER CELL, 2009, 15 (03) : 232 - 239
  • [4] VEGF-targeted therapy: mechanisms of anti-tumour activity
    Ellis, Lee M.
    Hicklin, Daniel J.
    [J]. NATURE REVIEWS CANCER, 2008, 8 (08) : 579 - 591
  • [5] Sorafenib in advanced clear-cell renal-cell carcinoma
    Escudier, Bernard
    Eisen, Tim
    Stadler, Walter M.
    Szczylik, Cezary
    Oudard, Stephane
    Siebels, Michael
    Negrier, Sylvie
    Chevreau, Christine
    Solska, Ewa
    Desai, Apurva A.
    Rolland, Frederic
    Demkow, Tomasz
    Hutson, Thomas E.
    Gore, Martin
    Freeman, Scott
    Schwartz, Brian
    Shan, Minghua
    Simantov, Ronit
    Bukowski, Ronald M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) : 125 - 134
  • [6] Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    Ferrara, N
    CarverMoore, K
    Chen, H
    Dowd, M
    Lu, L
    OShea, KS
    PowellBraxton, L
    Hillan, KJ
    Moore, MW
    [J]. NATURE, 1996, 380 (6573) : 439 - 442
  • [7] Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
    Grothey, Axel
    Sugrue, Mary M.
    Purdie, David M.
    Dong, Wei
    Sargent, Daniel
    Hedrick, Eric
    Kozloff, Mark
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) : 5326 - 5334
  • [8] KOPETZ S, 2009, P 2009 GASTR CANC S, P292
  • [9] Autocrine VEGF signaling is required for vascular homeostasis
    Lee, Sunyoung
    Chen, Tom T.
    Barber, Chad L.
    Jordan, Maria C.
    Murdock, Jared
    Desai, Sharina
    Ferrara, Napoleone
    Nagy, Andras
    Roos, Kenneth P.
    Iruela-Arispe, M. Luisa
    [J]. CELL, 2007, 130 (04) : 691 - 703
  • [10] Sorafenib in advanced hepatocellular carcinoma
    Llovet, Josep M.
    Ricci, Sergio
    Mazzaferro, Vincenzo
    Hilgard, Philip
    Gane, Edward
    Blanc, Jean-Frederic
    Cosme de Oliveira, Andre
    Santoro, Armando
    Raoul, Jean-Luc
    Forner, Alejandro
    Schwartz, Myron
    Porta, Camillo
    Zeuzem, Stefan
    Bolondi, Luigi
    Greten, Tim F.
    Galle, Peter R.
    Seitz, Jean-Francois
    Borbath, Ivan
    Haussinger, Dieter
    Giannaris, Tom
    Shan, Minghua
    Moscovici, Marius
    Voliotis, Dimitris
    Bruix, Jordi
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) : 378 - 390